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Rectal methohexital for sedation of children during imaging procedures.
AJR Am J Roentgenol 1993; 160(3):577-80AA

Abstract

OBJECTIVE

Brevital (methohexital), administered as a solution per rectum, provides safe, rapid, and effective sedation for induction of surgical anesthesia. This study was undertaken to evaluate rectal Brevital as a sedative for children undergoing imaging procedures.

MATERIALS AND METHODS

In a review of patients' records, we found that, during a 1-year period, 190 children from 1 month to 14 years old were sedated for CT or MR imaging. Sedation was required for 94 CT and 96 MR imaging studies. Rectal Brevital was used in 102 patients (mean age, 25 +/- 2 months), and oral chloral hydrate was used in 88 (mean age, 28 +/- 3 months).

RESULTS

Sleep was achieved in 81% of patients who received Brevital and in 80% of those who received chloral hydrate. Induction time was shorter (p = .0001) with Brevital (9 +/- 1 min) than with chloral hydrate (28 +/- 2 min). The mean duration of sleep was 46 min with Brevital and 66 min with chloral hydrate (p = .0001). Brevital provided adequate sedation in 89 (87%) of 102 imaging studies, and chloral hydrate did so in 73 (83%) of 88 studies. No cardiorespiratory complications or allergic reactions occurred with either drug. Significantly fewer patients were discharged fully awake and alert after sedation with chloral hydrate than with Brevital (p < .002). Children sedated with chloral hydrate also required a longer period of observation in the radiology department (p < .04).

CONCLUSION

We conclude that rectal Brevital produces sedation of adequate duration for most imaging procedures in children. Ease of administration, wide margin of safety, rapid and pleasant induction, and short recovery time make this drug a favorable alternative to other commonly used sedatives.

Authors+Show Affiliations

Department of Radiology, University of Rochester Medical Center, NY 14642.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8430557

Citation

Manuli, M A., and L Davies. "Rectal Methohexital for Sedation of Children During Imaging Procedures." AJR. American Journal of Roentgenology, vol. 160, no. 3, 1993, pp. 577-80.
Manuli MA, Davies L. Rectal methohexital for sedation of children during imaging procedures. AJR Am J Roentgenol. 1993;160(3):577-80.
Manuli, M. A., & Davies, L. (1993). Rectal methohexital for sedation of children during imaging procedures. AJR. American Journal of Roentgenology, 160(3), pp. 577-80.
Manuli MA, Davies L. Rectal Methohexital for Sedation of Children During Imaging Procedures. AJR Am J Roentgenol. 1993;160(3):577-80. PubMed PMID: 8430557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rectal methohexital for sedation of children during imaging procedures. AU - Manuli,M A, AU - Davies,L, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 577 EP - 80 JF - AJR. American journal of roentgenology JO - AJR Am J Roentgenol VL - 160 IS - 3 N2 - OBJECTIVE: Brevital (methohexital), administered as a solution per rectum, provides safe, rapid, and effective sedation for induction of surgical anesthesia. This study was undertaken to evaluate rectal Brevital as a sedative for children undergoing imaging procedures. MATERIALS AND METHODS: In a review of patients' records, we found that, during a 1-year period, 190 children from 1 month to 14 years old were sedated for CT or MR imaging. Sedation was required for 94 CT and 96 MR imaging studies. Rectal Brevital was used in 102 patients (mean age, 25 +/- 2 months), and oral chloral hydrate was used in 88 (mean age, 28 +/- 3 months). RESULTS: Sleep was achieved in 81% of patients who received Brevital and in 80% of those who received chloral hydrate. Induction time was shorter (p = .0001) with Brevital (9 +/- 1 min) than with chloral hydrate (28 +/- 2 min). The mean duration of sleep was 46 min with Brevital and 66 min with chloral hydrate (p = .0001). Brevital provided adequate sedation in 89 (87%) of 102 imaging studies, and chloral hydrate did so in 73 (83%) of 88 studies. No cardiorespiratory complications or allergic reactions occurred with either drug. Significantly fewer patients were discharged fully awake and alert after sedation with chloral hydrate than with Brevital (p < .002). Children sedated with chloral hydrate also required a longer period of observation in the radiology department (p < .04). CONCLUSION: We conclude that rectal Brevital produces sedation of adequate duration for most imaging procedures in children. Ease of administration, wide margin of safety, rapid and pleasant induction, and short recovery time make this drug a favorable alternative to other commonly used sedatives. SN - 0361-803X UR - https://www.unboundmedicine.com/medline/citation/8430557/Rectal_methohexital_for_sedation_of_children_during_imaging_procedures_ L2 - http://www.ajronline.org/doi/full/10.2214/ajr.160.3.8430557 DB - PRIME DP - Unbound Medicine ER -