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The structure of large and small airways in nonfatal and fatal asthma.
Am Rev Respir Dis. 1993 Feb; 147(2):405-10.AR

Abstract

Asthma is characterized by excessive airway narrowing and airway wall inflammation. In cases of fatal asthma, increased thickness of the airway wall is observed and may account for excessive airway narrowing when smooth muscle contracts. This study was undertaken to examine airway dimensions in large and small airways in both fatal and nonfatal cases of asthma. Airway wall areas (total, inner, and outer relative to smooth muscle layer), epithelial integrity, smooth muscle shortening, and the areas of smooth muscle, cartilage, and mucous glands were compared in transverse sections of large and small airways of subjects dying of asthma (fatal asthma, n = 11), those dying suddenly of nonrespiratory diseases and having a definite history of asthma (nonfatal asthma, n = 13), and those dying suddenly without any history of respiratory illness (control, n = 11). Airways were grouped by size using the basement membrane perimeter for comparison. All areas were expressed as areas per millimeter of basement membrane. In cartilaginous airways, the cases of fatal asthma had greater (p < 0.05) total wall, inner wall, outer wall, smooth muscle, mucous gland and cartilage areas than did control and nonfatal cases. The inner wall area was greater in the fatal and nonfatal cases than in the control cases (p < 0.05) in the small cartilaginous airways and membranous bronchioles (MB). In small MB (perimeter < 2 mm), the total and outer wall areas were greater (p < 0.05) in cases of fatal and nonfatal asthma than in control cases.(

ABSTRACT

TRUNCATED AT 250 WORDS)

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Authors+Show Affiliations

Carroll N
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia.
Elliot J
No affiliation info available
Morton A
No affiliation info available
James A
No affiliation info available

MeSH

AdolescentAdultAgedAnalysis of VarianceAsthmaBronchiDeath, SuddenFemaleHumansMaleMiddle AgedWestern Australia

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8430966

Citation

Carroll, N, et al. "The Structure of Large and Small Airways in Nonfatal and Fatal Asthma." The American Review of Respiratory Disease, vol. 147, no. 2, 1993, pp. 405-10.
Carroll N, Elliot J, Morton A, et al. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis. 1993;147(2):405-10.
Carroll, N., Elliot, J., Morton, A., & James, A. (1993). The structure of large and small airways in nonfatal and fatal asthma. The American Review of Respiratory Disease, 147(2), 405-10.
Carroll N, et al. The Structure of Large and Small Airways in Nonfatal and Fatal Asthma. Am Rev Respir Dis. 1993;147(2):405-10. PubMed PMID: 8430966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The structure of large and small airways in nonfatal and fatal asthma. AU - Carroll,N, AU - Elliot,J, AU - Morton,A, AU - James,A, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 405 EP - 10 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 147 IS - 2 N2 - Asthma is characterized by excessive airway narrowing and airway wall inflammation. In cases of fatal asthma, increased thickness of the airway wall is observed and may account for excessive airway narrowing when smooth muscle contracts. This study was undertaken to examine airway dimensions in large and small airways in both fatal and nonfatal cases of asthma. Airway wall areas (total, inner, and outer relative to smooth muscle layer), epithelial integrity, smooth muscle shortening, and the areas of smooth muscle, cartilage, and mucous glands were compared in transverse sections of large and small airways of subjects dying of asthma (fatal asthma, n = 11), those dying suddenly of nonrespiratory diseases and having a definite history of asthma (nonfatal asthma, n = 13), and those dying suddenly without any history of respiratory illness (control, n = 11). Airways were grouped by size using the basement membrane perimeter for comparison. All areas were expressed as areas per millimeter of basement membrane. In cartilaginous airways, the cases of fatal asthma had greater (p < 0.05) total wall, inner wall, outer wall, smooth muscle, mucous gland and cartilage areas than did control and nonfatal cases. The inner wall area was greater in the fatal and nonfatal cases than in the control cases (p < 0.05) in the small cartilaginous airways and membranous bronchioles (MB). In small MB (perimeter < 2 mm), the total and outer wall areas were greater (p < 0.05) in cases of fatal and nonfatal asthma than in control cases.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/8430966/The_structure_of_large_and_small_airways_in_nonfatal_and_fatal_asthma_ L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/147.2.405?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -