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Vasectomy, serum assays, and coronary heart disease symptoms and risk factors.
J Clin Epidemiol. 1993 Jan; 46(1):101-9.JC

Abstract

We compared three serum assays (two antisperm antibody assays and one assay for circulating immune complexes) and a number of CHD-related variables in 69 vasectomized (V) and 126 non-vasectomized (NV) participants in the Portland Center for the Multiple Risk Factor Intervention Trial. Significant differences between the V and NV men were found in sperm agglutination (SA) and sperm immobilization (SI) titers, as well as in several CHD risk factors, symptoms, and treatments; men in the V group had higher titers for SA and SI, smoked more, and had lower diastolic and systolic blood pressure than men in the NV group. Differences between V and NV in SA and SI activity remained even after we controlled for any effects that CHD risk factors, symptoms, and treatments may have had on the serum assays. Antibody development tended to decrease with age-at-vasectomy and increase with time-post-vasectomy. In the case of SA the antibodies clearly increased with time-post-vasectomy.

Authors+Show Affiliations

Kaiser Permanente Center for Health Research, Portland, OR 97227.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8433106

Citation

Mullooly, J P., et al. "Vasectomy, Serum Assays, and Coronary Heart Disease Symptoms and Risk Factors." Journal of Clinical Epidemiology, vol. 46, no. 1, 1993, pp. 101-9.
Mullooly JP, Wiest WM, Alexander NJ, et al. Vasectomy, serum assays, and coronary heart disease symptoms and risk factors. J Clin Epidemiol. 1993;46(1):101-9.
Mullooly, J. P., Wiest, W. M., Alexander, N. J., Greenlick, M. R., & Fulgham, D. L. (1993). Vasectomy, serum assays, and coronary heart disease symptoms and risk factors. Journal of Clinical Epidemiology, 46(1), 101-9.
Mullooly JP, et al. Vasectomy, Serum Assays, and Coronary Heart Disease Symptoms and Risk Factors. J Clin Epidemiol. 1993;46(1):101-9. PubMed PMID: 8433106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasectomy, serum assays, and coronary heart disease symptoms and risk factors. AU - Mullooly,J P, AU - Wiest,W M, AU - Alexander,N J, AU - Greenlick,M R, AU - Fulgham,D L, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez KW - Americas KW - Antibodies KW - Antibody Formation KW - Antigen-antibody Reactions KW - Biology KW - Cardiovascular Effects KW - Comparative Studies KW - Developed Countries KW - Diseases KW - Family Planning KW - Genitalia KW - Germ Cells KW - Heart Diseases KW - Immunity KW - Immunologic Factors KW - Male Sterilization KW - North America KW - Northern America KW - Physiology KW - Research Methodology KW - Research Report KW - Risk Factors KW - Sperm Agglutination KW - Spermatozoa KW - Sterilization, Sexual KW - Studies KW - United States KW - Urogenital System KW - Vasectomy SP - 101 EP - 9 JF - Journal of clinical epidemiology JO - J Clin Epidemiol VL - 46 IS - 1 N2 - We compared three serum assays (two antisperm antibody assays and one assay for circulating immune complexes) and a number of CHD-related variables in 69 vasectomized (V) and 126 non-vasectomized (NV) participants in the Portland Center for the Multiple Risk Factor Intervention Trial. Significant differences between the V and NV men were found in sperm agglutination (SA) and sperm immobilization (SI) titers, as well as in several CHD risk factors, symptoms, and treatments; men in the V group had higher titers for SA and SI, smoked more, and had lower diastolic and systolic blood pressure than men in the NV group. Differences between V and NV in SA and SI activity remained even after we controlled for any effects that CHD risk factors, symptoms, and treatments may have had on the serum assays. Antibody development tended to decrease with age-at-vasectomy and increase with time-post-vasectomy. In the case of SA the antibodies clearly increased with time-post-vasectomy. SN - 0895-4356 UR - https://www.unboundmedicine.com/medline/citation/8433106/Vasectomy_serum_assays_and_coronary_heart_disease_symptoms_and_risk_factors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0895-4356(93)90014-R DB - PRIME DP - Unbound Medicine ER -