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Primary osteoma cutis. Clinical, morphological, and ultrastructural study.
Am J Dermatopathol 1993; 15(1):77-81AJ

Abstract

Primary osteoma cutis arises in the deeper dermis for no apparent reason and presents as mature, lamellar, and osteonic bone; secondary cutaneous osteomas are correlated with inflammatory processes, scars, or dysembryoplasia and are always composed of osteoid. Ultrastructural findings of primary cutaneous osteomas have not been reported to date. Light and electron microscopic findings of a case of primary osteoma cutis are described: mineralized areas may be divided into macrocalcification and microcalcification. Macrocalcification consists of lamellar bone. Osteocytes populate the lamellae, whereas collagen fibril distribution is bone-like. Hydroxyapatite deposition presents as globular or needle-like electron-dense material progressively masking the connective tissue matrix. Microcalcifications, which are found in macroscopically normal dermis around the calcified plaque, consist of osteoid tissue inhabited by osteoblast-like cells. Microcalcifications may be interpreted as metastatic calcifications related to the primary osteoma calcified plaque. Primary osteoma cutis may be considered as true bone amartothic formation rather than dermal mineralization.

Authors+Show Affiliations

Clinic of Dermatology, University of Sassari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8434738

Citation

Cottoni, F, et al. "Primary Osteoma Cutis. Clinical, Morphological, and Ultrastructural Study." The American Journal of Dermatopathology, vol. 15, no. 1, 1993, pp. 77-81.
Cottoni F, Dell' Orbo C, Quacci D, et al. Primary osteoma cutis. Clinical, morphological, and ultrastructural study. Am J Dermatopathol. 1993;15(1):77-81.
Cottoni, F., Dell' Orbo, C., Quacci, D., & Tedde, G. (1993). Primary osteoma cutis. Clinical, morphological, and ultrastructural study. The American Journal of Dermatopathology, 15(1), pp. 77-81.
Cottoni F, et al. Primary Osteoma Cutis. Clinical, Morphological, and Ultrastructural Study. Am J Dermatopathol. 1993;15(1):77-81. PubMed PMID: 8434738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary osteoma cutis. Clinical, morphological, and ultrastructural study. AU - Cottoni,F, AU - Dell' Orbo,C, AU - Quacci,D, AU - Tedde,G, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 77 EP - 81 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 15 IS - 1 N2 - Primary osteoma cutis arises in the deeper dermis for no apparent reason and presents as mature, lamellar, and osteonic bone; secondary cutaneous osteomas are correlated with inflammatory processes, scars, or dysembryoplasia and are always composed of osteoid. Ultrastructural findings of primary cutaneous osteomas have not been reported to date. Light and electron microscopic findings of a case of primary osteoma cutis are described: mineralized areas may be divided into macrocalcification and microcalcification. Macrocalcification consists of lamellar bone. Osteocytes populate the lamellae, whereas collagen fibril distribution is bone-like. Hydroxyapatite deposition presents as globular or needle-like electron-dense material progressively masking the connective tissue matrix. Microcalcifications, which are found in macroscopically normal dermis around the calcified plaque, consist of osteoid tissue inhabited by osteoblast-like cells. Microcalcifications may be interpreted as metastatic calcifications related to the primary osteoma calcified plaque. Primary osteoma cutis may be considered as true bone amartothic formation rather than dermal mineralization. SN - 0193-1091 UR - https://www.unboundmedicine.com/medline/citation/8434738/Primary_osteoma_cutis__Clinical_morphological_and_ultrastructural_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8434738.ui DB - PRIME DP - Unbound Medicine ER -