Tags

Type your tag names separated by a space and hit enter

Pituitary apoplexy and sudden blindness following the administration of gonadotrophin releasing hormone.
Clin Endocrinol (Oxf). 1993 Jan; 38(1):109-10.CE

Abstract

Pituitary apoplexy has been reported as a rare complication of combined tests and of TRH administration in prolactinomas. A 54-year-old man with a pituitary macroadenoma had a single injection of 100 micrograms GnRH. Twenty minutes later he complained of increasing headache and vomited. These symptoms settled spontaneously and were attributed to the pharmacological effects of GnRH. Five hours later he was found to be blind and disorientated without spontaneous complaint. Emergency CT showed a large adenoma with central necrosis, consistent with pituitary apoplexy. An urgent surgical decompression was carried out and necrotic haemorrhagic debris removed. Baseline bloods revealed non-pulsatile FSH of 40 U/l with LH 0.3 U/l with no hormonal response to GnRH administration, but the sequence of events strongly suggests a causal relationship between this and pituitary apoplexy. To our knowledge this is the first time that GnRH administration has been associated with pituitary apoplexy of a glycoprotein secreting pituitary adenoma.

Links

Publisher Full Text

Authors+Show Affiliations

Masson EA
Department of Endocrinology, Royal Liverpool University Hospital, UK.
Atkin SL
No affiliation info available
Diver M
No affiliation info available
White MC
No affiliation info available

MeSH

AdenomaBlindnessGonadotropin-Releasing HormoneHumansMaleMiddle AgedPituitary ApoplexyPituitary Neoplasms

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

8435878

Citation

Masson, E A., et al. "Pituitary Apoplexy and Sudden Blindness Following the Administration of Gonadotrophin Releasing Hormone." Clinical Endocrinology, vol. 38, no. 1, 1993, pp. 109-10.
Masson EA, Atkin SL, Diver M, et al. Pituitary apoplexy and sudden blindness following the administration of gonadotrophin releasing hormone. Clin Endocrinol (Oxf). 1993;38(1):109-10.
Masson, E. A., Atkin, S. L., Diver, M., & White, M. C. (1993). Pituitary apoplexy and sudden blindness following the administration of gonadotrophin releasing hormone. Clinical Endocrinology, 38(1), 109-10.
Masson EA, et al. Pituitary Apoplexy and Sudden Blindness Following the Administration of Gonadotrophin Releasing Hormone. Clin Endocrinol (Oxf). 1993;38(1):109-10. PubMed PMID: 8435878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pituitary apoplexy and sudden blindness following the administration of gonadotrophin releasing hormone. AU - Masson,E A, AU - Atkin,S L, AU - Diver,M, AU - White,M C, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 109 EP - 10 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 38 IS - 1 N2 - Pituitary apoplexy has been reported as a rare complication of combined tests and of TRH administration in prolactinomas. A 54-year-old man with a pituitary macroadenoma had a single injection of 100 micrograms GnRH. Twenty minutes later he complained of increasing headache and vomited. These symptoms settled spontaneously and were attributed to the pharmacological effects of GnRH. Five hours later he was found to be blind and disorientated without spontaneous complaint. Emergency CT showed a large adenoma with central necrosis, consistent with pituitary apoplexy. An urgent surgical decompression was carried out and necrotic haemorrhagic debris removed. Baseline bloods revealed non-pulsatile FSH of 40 U/l with LH 0.3 U/l with no hormonal response to GnRH administration, but the sequence of events strongly suggests a causal relationship between this and pituitary apoplexy. To our knowledge this is the first time that GnRH administration has been associated with pituitary apoplexy of a glycoprotein secreting pituitary adenoma. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/8435878/Pituitary_apoplexy_and_sudden_blindness_following_the_administration_of_gonadotrophin_releasing_hormone_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=1993&volume=38&issue=1&spage=109 DB - PRIME DP - Unbound Medicine ER -