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Vasectomy and prostate cancer risk: methodological review of the evidence.
J Clin Epidemiol 1993; 46(2):163-72JC

Abstract

Two recent studies have reported a significantly elevated risk of prostate cancer among vasectomized men. To assess whether the new results conflict with earlier studies that found no significant overall association, and, if so, whether such a conflict could have a methodological basis, we reviewed the six major epidemiological studies of this topic. Statistical analysis revealed significant (p < 0.01) heterogeneity among the associations in the six studies, attributable to one of the recent studies. Scrutiny of the studies for fulfillment of eight methodological standards for scientific validity revealed that no study completely fulfilled more than four standards, and that all studies were deficient in avoiding detection bias and obtaining accurate vasectomy histories. Our review indicates that the evidence on this topic is indeed conflicting, that the quality of the evidence does not resolve the conflict, and that future studies of this topic, designed to ensure scientific credibility of results, are needed.

Authors+Show Affiliations

National Institute of Child Health and Human Development, Bethesda, MD 20892.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

8437032

Citation

DerSimonian, R, et al. "Vasectomy and Prostate Cancer Risk: Methodological Review of the Evidence." Journal of Clinical Epidemiology, vol. 46, no. 2, 1993, pp. 163-72.
DerSimonian R, Clemens J, Spirtas R, et al. Vasectomy and prostate cancer risk: methodological review of the evidence. J Clin Epidemiol. 1993;46(2):163-72.
DerSimonian, R., Clemens, J., Spirtas, R., & Perlman, J. (1993). Vasectomy and prostate cancer risk: methodological review of the evidence. Journal of Clinical Epidemiology, 46(2), pp. 163-72.
DerSimonian R, et al. Vasectomy and Prostate Cancer Risk: Methodological Review of the Evidence. J Clin Epidemiol. 1993;46(2):163-72. PubMed PMID: 8437032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasectomy and prostate cancer risk: methodological review of the evidence. AU - DerSimonian,R, AU - Clemens,J, AU - Spirtas,R, AU - Perlman,J, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez KW - Americas KW - Biology KW - Cancer KW - Developed Countries KW - Diseases KW - Family Planning KW - Genitalia KW - Genitalia, Male KW - Male Sterilization KW - Methodological Studies KW - Neoplasms KW - North America KW - Northern America KW - Physiology KW - Population At Risk--men KW - Prostate KW - Research Methodology KW - Sterilization, Sexual KW - United States KW - Urogenital System KW - Vasectomy SP - 163 EP - 72 JF - Journal of clinical epidemiology JO - J Clin Epidemiol VL - 46 IS - 2 N2 - Two recent studies have reported a significantly elevated risk of prostate cancer among vasectomized men. To assess whether the new results conflict with earlier studies that found no significant overall association, and, if so, whether such a conflict could have a methodological basis, we reviewed the six major epidemiological studies of this topic. Statistical analysis revealed significant (p < 0.01) heterogeneity among the associations in the six studies, attributable to one of the recent studies. Scrutiny of the studies for fulfillment of eight methodological standards for scientific validity revealed that no study completely fulfilled more than four standards, and that all studies were deficient in avoiding detection bias and obtaining accurate vasectomy histories. Our review indicates that the evidence on this topic is indeed conflicting, that the quality of the evidence does not resolve the conflict, and that future studies of this topic, designed to ensure scientific credibility of results, are needed. SN - 0895-4356 UR - https://www.unboundmedicine.com/medline/citation/8437032/Vasectomy_and_prostate_cancer_risk:_methodological_review_of_the_evidence_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0895-4356(93)90054-5 DB - PRIME DP - Unbound Medicine ER -