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Nucleation time and fatty acid composition of lecithin in human gallbladder bile.
Scand J Gastroenterol 1993; 28(2):131-6SJ

Abstract

We investigated the relationship between bile nucleation time and the fatty acid composition of biliary lecithin in human gallbladder bile. Bile samples from patients with cholesterol gallstones nucleated more rapidly than those from patients with noncholesterol gallstones or no stones. The biliary cholesterol concentration was highest in the cholesterol gallstone group and was correlated with the molar percentage of linoleic acid and arachidonic acid, with these percentages also being higher in bile from the cholesterol gallstone patients than in bile from the other two groups. In addition, the mucous glycoprotein concentration in bile was also significantly higher in the cholesterol gallstone group. Thirty-three patients in the no-stone group showed bile nucleation times of less than 21 days. Higher concentrations of cholesterol and mucous glycoprotein and higher molar percentages of arachidonic and linoleic acid were noted in these patients. These findings suggest that in humans, hepatic cholesterol hypersecretion is associated with the increased unsaturated fatty acid proportion in biliary phospholipids and gallbladder mucin hypersecretion, thereby causing rapid cholesterol crystal nucleation.

Authors+Show Affiliations

First Dept. of Internal Medicine, Hiroshima University School of Medicine, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8441906

Citation

Hatsushika, S, et al. "Nucleation Time and Fatty Acid Composition of Lecithin in Human Gallbladder Bile." Scandinavian Journal of Gastroenterology, vol. 28, no. 2, 1993, pp. 131-6.
Hatsushika S, Tazuma S, Kajiyama G. Nucleation time and fatty acid composition of lecithin in human gallbladder bile. Scand J Gastroenterol. 1993;28(2):131-6.
Hatsushika, S., Tazuma, S., & Kajiyama, G. (1993). Nucleation time and fatty acid composition of lecithin in human gallbladder bile. Scandinavian Journal of Gastroenterology, 28(2), pp. 131-6.
Hatsushika S, Tazuma S, Kajiyama G. Nucleation Time and Fatty Acid Composition of Lecithin in Human Gallbladder Bile. Scand J Gastroenterol. 1993;28(2):131-6. PubMed PMID: 8441906.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nucleation time and fatty acid composition of lecithin in human gallbladder bile. AU - Hatsushika,S, AU - Tazuma,S, AU - Kajiyama,G, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 131 EP - 6 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 28 IS - 2 N2 - We investigated the relationship between bile nucleation time and the fatty acid composition of biliary lecithin in human gallbladder bile. Bile samples from patients with cholesterol gallstones nucleated more rapidly than those from patients with noncholesterol gallstones or no stones. The biliary cholesterol concentration was highest in the cholesterol gallstone group and was correlated with the molar percentage of linoleic acid and arachidonic acid, with these percentages also being higher in bile from the cholesterol gallstone patients than in bile from the other two groups. In addition, the mucous glycoprotein concentration in bile was also significantly higher in the cholesterol gallstone group. Thirty-three patients in the no-stone group showed bile nucleation times of less than 21 days. Higher concentrations of cholesterol and mucous glycoprotein and higher molar percentages of arachidonic and linoleic acid were noted in these patients. These findings suggest that in humans, hepatic cholesterol hypersecretion is associated with the increased unsaturated fatty acid proportion in biliary phospholipids and gallbladder mucin hypersecretion, thereby causing rapid cholesterol crystal nucleation. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/8441906/Nucleation_time_and_fatty_acid_composition_of_lecithin_in_human_gallbladder_bile_ L2 - http://www.tandfonline.com/doi/full/10.3109/00365529309096059 DB - PRIME DP - Unbound Medicine ER -