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The effect of topical application of vasodilating agents on cochlear electrophysiology.
Acta Otolaryngol. 1993 Jan; 113(1):55-61.AO

Abstract

The aim of this investigation was to study whether increased blood flow has beneficial effects on the ear or whether it is damaging to the auditory function, expressed as the auditory gross neural response. Four vasodilating agents were examined after topical application with respect to their influence on cochlear blood flow (CBF), blood pressure, and auditory function in the normal guinea pig. CBF was recorded with laser-Doppler. The drugs used were sodium nitroprusside, hydralazine, nicotinic acid and histamine. Sodium nitroprusside and hydralazine increased CBF and induced concentration dependent loss of auditory function. Neither nicotinic acid nor histamine had any effect on CBF. Nicotinic acid had varying effects: in some cases a negative influence on threshold shifts was seen, and in others a positive one. In most cases histamine caused improvement of the auditory function. The data indicate that topical administration of drugs to the inner ear is effective to influence both CBF and auditory function.

Authors+Show Affiliations

Department of Otorhinolaryngology, University Hospital, Uppsala, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8442423

Citation

Ohlsén, A, et al. "The Effect of Topical Application of Vasodilating Agents On Cochlear Electrophysiology." Acta Oto-laryngologica, vol. 113, no. 1, 1993, pp. 55-61.
Ohlsén A, Hultcrantz E, Engström B. The effect of topical application of vasodilating agents on cochlear electrophysiology. Acta Otolaryngol. 1993;113(1):55-61.
Ohlsén, A., Hultcrantz, E., & Engström, B. (1993). The effect of topical application of vasodilating agents on cochlear electrophysiology. Acta Oto-laryngologica, 113(1), 55-61.
Ohlsén A, Hultcrantz E, Engström B. The Effect of Topical Application of Vasodilating Agents On Cochlear Electrophysiology. Acta Otolaryngol. 1993;113(1):55-61. PubMed PMID: 8442423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of topical application of vasodilating agents on cochlear electrophysiology. AU - Ohlsén,A, AU - Hultcrantz,E, AU - Engström,B, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 55 EP - 61 JF - Acta oto-laryngologica JO - Acta Otolaryngol. VL - 113 IS - 1 N2 - The aim of this investigation was to study whether increased blood flow has beneficial effects on the ear or whether it is damaging to the auditory function, expressed as the auditory gross neural response. Four vasodilating agents were examined after topical application with respect to their influence on cochlear blood flow (CBF), blood pressure, and auditory function in the normal guinea pig. CBF was recorded with laser-Doppler. The drugs used were sodium nitroprusside, hydralazine, nicotinic acid and histamine. Sodium nitroprusside and hydralazine increased CBF and induced concentration dependent loss of auditory function. Neither nicotinic acid nor histamine had any effect on CBF. Nicotinic acid had varying effects: in some cases a negative influence on threshold shifts was seen, and in others a positive one. In most cases histamine caused improvement of the auditory function. The data indicate that topical administration of drugs to the inner ear is effective to influence both CBF and auditory function. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/8442423/The_effect_of_topical_application_of_vasodilating_agents_on_cochlear_electrophysiology_ L2 - http://www.tandfonline.com/doi/full/10.3109/00016489309135767 DB - PRIME DP - Unbound Medicine ER -