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Improved treatment of Paget's disease with dimethylaminohydroxypropylidene bisphosphonate.
J Bone Miner Res. 1993 Feb; 8(2):175-82.JB

Abstract

A group of 89 patients with Paget's disease of bone were treated with different intravenous or oral doses of the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate (dimethyl-APD). Biochemical remission was obtained in 82% of treatments, and in the rest a clear response was found. Oral dimethyl-APD was well tolerated, and a dose of 200 mg/day for 10 days was sufficient to induce remission in the majority of patients. The remission probability was 3 months for 50% of patients, and the recurrence-free period was 27 months. The remission probability as well as the recurrence-free period did not differ among oral and intravenous treatments or among patients who had never been treated with nitrogen-containing bisphosphonates and those who had received pamidronate in the past and were treated for a recurrence of the disease. Dimethyl-APD is a very effective bisphosphonate devoid of side effects, which given for a short period can induce long-lasting remissions in patients with Paget's disease of bone.

Authors+Show Affiliations

Department of Endocrinology and Metabolic Diseases, University Hospital, Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8442435

Citation

Schweitzer, D H., et al. "Improved Treatment of Paget's Disease With Dimethylaminohydroxypropylidene Bisphosphonate." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 8, no. 2, 1993, pp. 175-82.
Schweitzer DH, Zwinderman AH, Vermeij P, et al. Improved treatment of Paget's disease with dimethylaminohydroxypropylidene bisphosphonate. J Bone Miner Res. 1993;8(2):175-82.
Schweitzer, D. H., Zwinderman, A. H., Vermeij, P., Bijvoet, O. L., & Papapoulos, S. E. (1993). Improved treatment of Paget's disease with dimethylaminohydroxypropylidene bisphosphonate. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 8(2), 175-82.
Schweitzer DH, et al. Improved Treatment of Paget's Disease With Dimethylaminohydroxypropylidene Bisphosphonate. J Bone Miner Res. 1993;8(2):175-82. PubMed PMID: 8442435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved treatment of Paget's disease with dimethylaminohydroxypropylidene bisphosphonate. AU - Schweitzer,D H, AU - Zwinderman,A H, AU - Vermeij,P, AU - Bijvoet,O L, AU - Papapoulos,S E, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 175 EP - 82 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 8 IS - 2 N2 - A group of 89 patients with Paget's disease of bone were treated with different intravenous or oral doses of the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate (dimethyl-APD). Biochemical remission was obtained in 82% of treatments, and in the rest a clear response was found. Oral dimethyl-APD was well tolerated, and a dose of 200 mg/day for 10 days was sufficient to induce remission in the majority of patients. The remission probability was 3 months for 50% of patients, and the recurrence-free period was 27 months. The remission probability as well as the recurrence-free period did not differ among oral and intravenous treatments or among patients who had never been treated with nitrogen-containing bisphosphonates and those who had received pamidronate in the past and were treated for a recurrence of the disease. Dimethyl-APD is a very effective bisphosphonate devoid of side effects, which given for a short period can induce long-lasting remissions in patients with Paget's disease of bone. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/8442435/Improved_treatment_of_Paget's_disease_with_dimethylaminohydroxypropylidene_bisphosphonate_ L2 - https://doi.org/10.1002/jbmr.5650080208 DB - PRIME DP - Unbound Medicine ER -