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[The importance of hypergastrinemia in the diagnosis of Biermer's disease in the adult].
Ann Gastroenterol Hepatol (Paris). 1993 Jan-Feb; 29(1):42-5.AG

Abstract

Achlorhydria that is due to antrum sparring atrophic gastritis is a characteristic finding in pernicious anemia. As a consequence of this achlorhydria serum gastrin level rise. Usually several signs are required for assessing a pernicious anemia: megaloblastic anemia, low serum cobalamin level, positivity of a Schilling test, low level of intrinsic factor in the gastric juice, existence of anti-intrinsic factor antibodies in plasma and/or in gastric juice. In this study the usefulness of the serum gastrin level is assessed. We report here the results in investigating sixteen patients with a pernicious anemia. All had: megaloblastic changes on bone marrow examination, serum cobalamin level lower than 150 pg/ml. For 14 patients the performed Schilling test was positive. For 2, no Schilling test was done, but anti-intrinsic factor antibodies were elevated. Serum gastrin levels were higher than 150 pg/ml (254 to 1770 pg/ml). In our patients with pernicious anemia, as a result of hypo or achlorhydria, serum gastrin increase was higher than in any other cause of hypochlorhydria: anti-acid treatment, vagotomy ... Measurement of serum gastrin is easy. High levels are simple to explain if found together with a sparing antrum atrophic gastritis and/or a low level of serum cobalamin. Serum gastrin measurement may be a cornerstone of rapid and reliable diagnosis of pernicious anemia.

Authors+Show Affiliations

Médecine interne, Groupe Hospitalier de la Timone Adultes, Marseille.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

8442653

Citation

Mongin, M, et al. "[The Importance of Hypergastrinemia in the Diagnosis of Biermer's Disease in the Adult]." Annales De Gastroenterologie Et D'hepatologie, vol. 29, no. 1, 1993, pp. 42-5.
Mongin M, Harle JR, Weiller PJ. [The importance of hypergastrinemia in the diagnosis of Biermer's disease in the adult]. Ann Gastroenterol Hepatol (Paris). 1993;29(1):42-5.
Mongin, M., Harle, J. R., & Weiller, P. J. (1993). [The importance of hypergastrinemia in the diagnosis of Biermer's disease in the adult]. Annales De Gastroenterologie Et D'hepatologie, 29(1), 42-5.
Mongin M, Harle JR, Weiller PJ. [The Importance of Hypergastrinemia in the Diagnosis of Biermer's Disease in the Adult]. Ann Gastroenterol Hepatol (Paris). 1993 Jan-Feb;29(1):42-5. PubMed PMID: 8442653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The importance of hypergastrinemia in the diagnosis of Biermer's disease in the adult]. AU - Mongin,M, AU - Harle,J R, AU - Weiller,P J, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 42 EP - 5 JF - Annales de gastroenterologie et d'hepatologie JO - Ann Gastroenterol Hepatol (Paris) VL - 29 IS - 1 N2 - Achlorhydria that is due to antrum sparring atrophic gastritis is a characteristic finding in pernicious anemia. As a consequence of this achlorhydria serum gastrin level rise. Usually several signs are required for assessing a pernicious anemia: megaloblastic anemia, low serum cobalamin level, positivity of a Schilling test, low level of intrinsic factor in the gastric juice, existence of anti-intrinsic factor antibodies in plasma and/or in gastric juice. In this study the usefulness of the serum gastrin level is assessed. We report here the results in investigating sixteen patients with a pernicious anemia. All had: megaloblastic changes on bone marrow examination, serum cobalamin level lower than 150 pg/ml. For 14 patients the performed Schilling test was positive. For 2, no Schilling test was done, but anti-intrinsic factor antibodies were elevated. Serum gastrin levels were higher than 150 pg/ml (254 to 1770 pg/ml). In our patients with pernicious anemia, as a result of hypo or achlorhydria, serum gastrin increase was higher than in any other cause of hypochlorhydria: anti-acid treatment, vagotomy ... Measurement of serum gastrin is easy. High levels are simple to explain if found together with a sparing antrum atrophic gastritis and/or a low level of serum cobalamin. Serum gastrin measurement may be a cornerstone of rapid and reliable diagnosis of pernicious anemia. SN - 0066-2070 UR - https://www.unboundmedicine.com/medline/citation/8442653/[The_importance_of_hypergastrinemia_in_the_diagnosis_of_Biermer's_disease_in_the_adult]_ DB - PRIME DP - Unbound Medicine ER -