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HIV infection and severe malnutrition: a clinical and epidemiological study in Burkina Faso.
AIDS. 1993 Jan; 7(1):103-8.AIDS

Abstract

OBJECTIVE

To define a clinical profile indicative of HIV infection in a population of severely malnourished children in Burkina Faso. A total of 433 children (average age, 19 months) were recruited at the Sanou Souro National Hospital, Bobo Dioulasso, Burkina Faso.

RESULTS

Sixty-three per cent presented with marasmus, 13% with kwashiorkor and 24% with both forms of malnutrition. The prevalence of HIV infection in children aged over 12 months was 13.8%, with a marked predominance of HIV-1 (95.8%). Mother-to-child transmission was proven in 77% of the cases; in 10% of the observed paediatric AIDS cases, transmission may have occurred through multi-injections with contaminated equipment. Marasmus was the form of malnutrition most frequently associated with HIV (P < 0.001); its severity was exacerbated by HIV infection. Adenopathy (P < 0.0001), oral candidiasis (P < 0.0006), skin disorders (P < 0.01) and hepatomegaly (P = 0.01) appeared to be significantly related to HIV infection. Discriminant analysis revealed that the presence of adenopathies was the strongest indicator symptom of HIV infection. Multivariate analysis revealed that a clinical profile of marasmus, adenopathies and oral candidiasis (specificity, 82%) was indicative of HIV infection in this population. The short-term clinical prognosis was poor and usually led to the death of the child when seropositive (P < 0.001).

CONCLUSIONS

Among children exhibiting severe malnutrition, HIV-positive children are distinguished by a high horizontal transmission rate, a high specific clinical profile and a very poor prognosis.

Authors+Show Affiliations

Groupe d'Etudes Epidémiologiques et Prophylactiques (GEEP), Villeneuve St Georges, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8442899

Citation

Prazuck, T, et al. "HIV Infection and Severe Malnutrition: a Clinical and Epidemiological Study in Burkina Faso." AIDS (London, England), vol. 7, no. 1, 1993, pp. 103-8.
Prazuck T, Tall F, Nacro B, et al. HIV infection and severe malnutrition: a clinical and epidemiological study in Burkina Faso. AIDS. 1993;7(1):103-8.
Prazuck, T., Tall, F., Nacro, B., Rochereau, A., Traore, A., Sanou, T., Malkin, J. E., Apaire-Marchais, V., Masson, D., & Dublanchet, A. (1993). HIV infection and severe malnutrition: a clinical and epidemiological study in Burkina Faso. AIDS (London, England), 7(1), 103-8.
Prazuck T, et al. HIV Infection and Severe Malnutrition: a Clinical and Epidemiological Study in Burkina Faso. AIDS. 1993;7(1):103-8. PubMed PMID: 8442899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HIV infection and severe malnutrition: a clinical and epidemiological study in Burkina Faso. A1 - Prazuck,T, AU - Tall,F, AU - Nacro,B, AU - Rochereau,A, AU - Traore,A, AU - Sanou,T, AU - Malkin,J E, AU - Apaire-Marchais,V, AU - Masson,D, AU - Dublanchet,A, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez KW - Acquired Immunodeficiency Syndrome KW - Africa KW - Africa South Of The Sahara KW - Age Factors KW - Burkina Faso KW - Child KW - Demographic Factors KW - Developing Countries KW - Diseases KW - Epidemiology KW - Examinations And Diagnoses KW - French Speaking Africa KW - Health KW - Hiv Infections KW - Infant KW - Malnutrition KW - Measurement KW - Nutrition Disorders KW - Physical Examinations And Diagnoses KW - Population KW - Population Characteristics KW - Prevalence KW - Public Health KW - Research Methodology KW - Research Report KW - Signs And Symptoms KW - Viral Diseases KW - Western Africa KW - Youth SP - 103 EP - 8 JF - AIDS (London, England) JO - AIDS VL - 7 IS - 1 N2 - OBJECTIVE: To define a clinical profile indicative of HIV infection in a population of severely malnourished children in Burkina Faso. A total of 433 children (average age, 19 months) were recruited at the Sanou Souro National Hospital, Bobo Dioulasso, Burkina Faso. RESULTS: Sixty-three per cent presented with marasmus, 13% with kwashiorkor and 24% with both forms of malnutrition. The prevalence of HIV infection in children aged over 12 months was 13.8%, with a marked predominance of HIV-1 (95.8%). Mother-to-child transmission was proven in 77% of the cases; in 10% of the observed paediatric AIDS cases, transmission may have occurred through multi-injections with contaminated equipment. Marasmus was the form of malnutrition most frequently associated with HIV (P < 0.001); its severity was exacerbated by HIV infection. Adenopathy (P < 0.0001), oral candidiasis (P < 0.0006), skin disorders (P < 0.01) and hepatomegaly (P = 0.01) appeared to be significantly related to HIV infection. Discriminant analysis revealed that the presence of adenopathies was the strongest indicator symptom of HIV infection. Multivariate analysis revealed that a clinical profile of marasmus, adenopathies and oral candidiasis (specificity, 82%) was indicative of HIV infection in this population. The short-term clinical prognosis was poor and usually led to the death of the child when seropositive (P < 0.001). CONCLUSIONS: Among children exhibiting severe malnutrition, HIV-positive children are distinguished by a high horizontal transmission rate, a high specific clinical profile and a very poor prognosis. SN - 0269-9370 UR - https://www.unboundmedicine.com/medline/citation/8442899/HIV_infection_and_severe_malnutrition:_a_clinical_and_epidemiological_study_in_Burkina_Faso_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=8442899.ui DB - PRIME DP - Unbound Medicine ER -