TY - JOUR T1 - HIV infection and severe malnutrition: a clinical and epidemiological study in Burkina Faso. A1 - Prazuck,T, AU - Tall,F, AU - Nacro,B, AU - Rochereau,A, AU - Traore,A, AU - Sanou,T, AU - Malkin,J E, AU - Apaire-Marchais,V, AU - Masson,D, AU - Dublanchet,A, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez KW - Acquired Immunodeficiency Syndrome KW - Africa KW - Africa South Of The Sahara KW - Age Factors KW - Burkina Faso KW - Child KW - Demographic Factors KW - Developing Countries KW - Diseases KW - Epidemiology KW - Examinations And Diagnoses KW - French Speaking Africa KW - Health KW - Hiv Infections KW - Infant KW - Malnutrition KW - Measurement KW - Nutrition Disorders KW - Physical Examinations And Diagnoses KW - Population KW - Population Characteristics KW - Prevalence KW - Public Health KW - Research Methodology KW - Research Report KW - Signs And Symptoms KW - Viral Diseases KW - Western Africa KW - Youth SP - 103 EP - 8 JF - AIDS (London, England) JO - AIDS VL - 7 IS - 1 N2 - OBJECTIVE: To define a clinical profile indicative of HIV infection in a population of severely malnourished children in Burkina Faso. A total of 433 children (average age, 19 months) were recruited at the Sanou Souro National Hospital, Bobo Dioulasso, Burkina Faso. RESULTS: Sixty-three per cent presented with marasmus, 13% with kwashiorkor and 24% with both forms of malnutrition. The prevalence of HIV infection in children aged over 12 months was 13.8%, with a marked predominance of HIV-1 (95.8%). Mother-to-child transmission was proven in 77% of the cases; in 10% of the observed paediatric AIDS cases, transmission may have occurred through multi-injections with contaminated equipment. Marasmus was the form of malnutrition most frequently associated with HIV (P < 0.001); its severity was exacerbated by HIV infection. Adenopathy (P < 0.0001), oral candidiasis (P < 0.0006), skin disorders (P < 0.01) and hepatomegaly (P = 0.01) appeared to be significantly related to HIV infection. Discriminant analysis revealed that the presence of adenopathies was the strongest indicator symptom of HIV infection. Multivariate analysis revealed that a clinical profile of marasmus, adenopathies and oral candidiasis (specificity, 82%) was indicative of HIV infection in this population. The short-term clinical prognosis was poor and usually led to the death of the child when seropositive (P < 0.001). CONCLUSIONS: Among children exhibiting severe malnutrition, HIV-positive children are distinguished by a high horizontal transmission rate, a high specific clinical profile and a very poor prognosis. SN - 0269-9370 UR - https://www.unboundmedicine.com/medline/citation/8442899/HIV_infection_and_severe_malnutrition:_a_clinical_and_epidemiological_study_in_Burkina_Faso_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=8442899.ui DB - PRIME DP - Unbound Medicine ER -