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Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy.
Int J Dermatol 1993; 32(3):210-3IJ

Abstract

BACKGROUND

Trophic ulceration, one of the most common complications of leprosy, is disabling, distressing, and demoralizing for the patient.

METHODS

The wound healing effects of topical phenytoin powder were compared with those of normal saline in a controlled in-patient study of 100 patients with 110 trophic leprosy ulcers of varying chronicity, over a 4-week study period. Fifty patients were assigned to the topical phenytoin group and 50 to saline therapy group. Ten patients had two ulcers each, and, in these cases, one ulcer was treated with phenytoin and the other with saline.

RESULTS

Over the 4-week treatment period healthy granulation tissue appeared earlier, and mean percentage of ulcer volume reduction was greater, in the phenytoin group (72.1 +/- 19.9% versus 55.5 +/- 21.6%) compared with the control group.

CONCLUSIONS

This difference was statistically significant at the level of P < 0.001. Phenytoin appears to be a useful agent for the promotion of healing of trophic leprosy ulcers.

Authors+Show Affiliations

Department of Dermatology, STD, and Leprosy, RNT Medical College, Rajasthan, India.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8444537

Citation

Bansal, N K., and Mukul. "Comparison of Topical Phenytoin With Normal Saline in the Treatment of Chronic Trophic Ulcers in Leprosy." International Journal of Dermatology, vol. 32, no. 3, 1993, pp. 210-3.
Bansal NK, Mukul . Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy. Int J Dermatol. 1993;32(3):210-3.
Bansal, N. K., & Mukul, . (1993). Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy. International Journal of Dermatology, 32(3), pp. 210-3.
Bansal NK, Mukul . Comparison of Topical Phenytoin With Normal Saline in the Treatment of Chronic Trophic Ulcers in Leprosy. Int J Dermatol. 1993;32(3):210-3. PubMed PMID: 8444537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy. AU - Bansal,N K, AU - Mukul,, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 210 EP - 3 JF - International journal of dermatology JO - Int. J. Dermatol. VL - 32 IS - 3 N2 - BACKGROUND: Trophic ulceration, one of the most common complications of leprosy, is disabling, distressing, and demoralizing for the patient. METHODS: The wound healing effects of topical phenytoin powder were compared with those of normal saline in a controlled in-patient study of 100 patients with 110 trophic leprosy ulcers of varying chronicity, over a 4-week study period. Fifty patients were assigned to the topical phenytoin group and 50 to saline therapy group. Ten patients had two ulcers each, and, in these cases, one ulcer was treated with phenytoin and the other with saline. RESULTS: Over the 4-week treatment period healthy granulation tissue appeared earlier, and mean percentage of ulcer volume reduction was greater, in the phenytoin group (72.1 +/- 19.9% versus 55.5 +/- 21.6%) compared with the control group. CONCLUSIONS: This difference was statistically significant at the level of P < 0.001. Phenytoin appears to be a useful agent for the promotion of healing of trophic leprosy ulcers. SN - 0011-9059 UR - https://www.unboundmedicine.com/medline/citation/8444537/Comparison_of_topical_phenytoin_with_normal_saline_in_the_treatment_of_chronic_trophic_ulcers_in_leprosy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0011-9059&amp;date=1993&amp;volume=32&amp;issue=3&amp;spage=210 DB - PRIME DP - Unbound Medicine ER -