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Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy.

Abstract

BACKGROUND

Trophic ulceration, one of the most common complications of leprosy, is disabling, distressing, and demoralizing for the patient.

METHODS

The wound healing effects of topical phenytoin powder were compared with those of normal saline in a controlled in-patient study of 100 patients with 110 trophic leprosy ulcers of varying chronicity, over a 4-week study period. Fifty patients were assigned to the topical phenytoin group and 50 to saline therapy group. Ten patients had two ulcers each, and, in these cases, one ulcer was treated with phenytoin and the other with saline.

RESULTS

Over the 4-week treatment period healthy granulation tissue appeared earlier, and mean percentage of ulcer volume reduction was greater, in the phenytoin group (72.1 +/- 19.9% versus 55.5 +/- 21.6%) compared with the control group.

CONCLUSIONS

This difference was statistically significant at the level of P < 0.001. Phenytoin appears to be a useful agent for the promotion of healing of trophic leprosy ulcers.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Dermatology, STD, and Leprosy, RNT Medical College, Rajasthan, India.

    Source

    MeSH

    Administration, Topical
    Adult
    Chronic Disease
    Female
    Humans
    Leprosy
    Male
    Middle Aged
    Phenytoin
    Prospective Studies
    Sodium Chloride
    Ulcer

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Controlled Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8444537

    Citation

    Bansal, N K., and Mukul. "Comparison of Topical Phenytoin With Normal Saline in the Treatment of Chronic Trophic Ulcers in Leprosy." International Journal of Dermatology, vol. 32, no. 3, 1993, pp. 210-3.
    Bansal NK, Mukul . Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy. Int J Dermatol. 1993;32(3):210-3.
    Bansal, N. K., & Mukul, . (1993). Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy. International Journal of Dermatology, 32(3), pp. 210-3.
    Bansal NK, Mukul . Comparison of Topical Phenytoin With Normal Saline in the Treatment of Chronic Trophic Ulcers in Leprosy. Int J Dermatol. 1993;32(3):210-3. PubMed PMID: 8444537.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy. AU - Bansal,N K, AU - Mukul,, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 210 EP - 3 JF - International journal of dermatology JO - Int. J. Dermatol. VL - 32 IS - 3 N2 - BACKGROUND: Trophic ulceration, one of the most common complications of leprosy, is disabling, distressing, and demoralizing for the patient. METHODS: The wound healing effects of topical phenytoin powder were compared with those of normal saline in a controlled in-patient study of 100 patients with 110 trophic leprosy ulcers of varying chronicity, over a 4-week study period. Fifty patients were assigned to the topical phenytoin group and 50 to saline therapy group. Ten patients had two ulcers each, and, in these cases, one ulcer was treated with phenytoin and the other with saline. RESULTS: Over the 4-week treatment period healthy granulation tissue appeared earlier, and mean percentage of ulcer volume reduction was greater, in the phenytoin group (72.1 +/- 19.9% versus 55.5 +/- 21.6%) compared with the control group. CONCLUSIONS: This difference was statistically significant at the level of P < 0.001. Phenytoin appears to be a useful agent for the promotion of healing of trophic leprosy ulcers. SN - 0011-9059 UR - https://www.unboundmedicine.com/medline/citation/8444537/Comparison_of_topical_phenytoin_with_normal_saline_in_the_treatment_of_chronic_trophic_ulcers_in_leprosy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0011-9059&amp;date=1993&amp;volume=32&amp;issue=3&amp;spage=210 DB - PRIME DP - Unbound Medicine ER -