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Topical phenytoin in wound healing.

Abstract

BACKGROUND

Phenytoin, introduced in 1937 as an antiseizure medication, has since been reported to promote wound healing when applied as a topical agent. This study was undertaken to evaluate its effectiveness in chronic skin ulcers.

METHODS

Seventy-five inpatients with chronic skin ulcers were included in this controlled trial. Forty patients were treated with topical phenytoin, and 35 patients with conventional saline dressings. Assessment of the wounds included wound area, bacteriologic cultures, and clinical assessment by blind observers at baseline and every 7 days thereafter over the 4-week treatment period.

RESULTS

Wound area reduction was greater in the phenytoin group than in controls. Fifty percent of phenytoin-treated wounds had negative cultures by day 7, compared to 17% of controls. Healthy granulation tissue appeared earlier with phenytoin. At the end of the fourth week, 29 of 40 phenytoin-treated ulcers had healed completely versus 10 of 35 controls.

CONCLUSIONS

Topical phenytoin appears to be an effective, inexpensive, and widely available therapeutic agent in wound healing. Further clinical use and evaluation is merited.

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  • Authors+Show Affiliations

    ,

    Department of Surgery, Ravindra Nath Tagore Medical College, Udaipur, Rajasthan, India.

    , ,

    Source

    MeSH

    Administration, Topical
    Adult
    Chronic Disease
    Female
    Humans
    Male
    Phenytoin
    Skin Ulcer
    Wound Healing

    Pub Type(s)

    Clinical Trial
    Controlled Clinical Trial
    Journal Article

    Language

    eng

    PubMed ID

    8444538

    Citation

    Pendse, A K., et al. "Topical Phenytoin in Wound Healing." International Journal of Dermatology, vol. 32, no. 3, 1993, pp. 214-7.
    Pendse AK, Sharma A, Sodani A, et al. Topical phenytoin in wound healing. Int J Dermatol. 1993;32(3):214-7.
    Pendse, A. K., Sharma, A., Sodani, A., & Hada, S. (1993). Topical phenytoin in wound healing. International Journal of Dermatology, 32(3), pp. 214-7.
    Pendse AK, et al. Topical Phenytoin in Wound Healing. Int J Dermatol. 1993;32(3):214-7. PubMed PMID: 8444538.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Topical phenytoin in wound healing. AU - Pendse,A K, AU - Sharma,A, AU - Sodani,A, AU - Hada,S, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 214 EP - 7 JF - International journal of dermatology JO - Int. J. Dermatol. VL - 32 IS - 3 N2 - BACKGROUND: Phenytoin, introduced in 1937 as an antiseizure medication, has since been reported to promote wound healing when applied as a topical agent. This study was undertaken to evaluate its effectiveness in chronic skin ulcers. METHODS: Seventy-five inpatients with chronic skin ulcers were included in this controlled trial. Forty patients were treated with topical phenytoin, and 35 patients with conventional saline dressings. Assessment of the wounds included wound area, bacteriologic cultures, and clinical assessment by blind observers at baseline and every 7 days thereafter over the 4-week treatment period. RESULTS: Wound area reduction was greater in the phenytoin group than in controls. Fifty percent of phenytoin-treated wounds had negative cultures by day 7, compared to 17% of controls. Healthy granulation tissue appeared earlier with phenytoin. At the end of the fourth week, 29 of 40 phenytoin-treated ulcers had healed completely versus 10 of 35 controls. CONCLUSIONS: Topical phenytoin appears to be an effective, inexpensive, and widely available therapeutic agent in wound healing. Further clinical use and evaluation is merited. SN - 0011-9059 UR - https://www.unboundmedicine.com/medline/citation/8444538/Topical_phenytoin_in_wound_healing_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0011-9059&date=1993&volume=32&issue=3&spage=214 DB - PRIME DP - Unbound Medicine ER -