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Activation of mesolimbic dopaminergic neurons following central administration of histamine is mediated by H1 receptors.
Naunyn Schmiedebergs Arch Pharmacol. 1993 Jan; 347(1):50-4.NS

Abstract

The effect of intracerebroventricular administration of histamine on the activity of mesolimbic and nigrostriatal dopaminergic (DA) neurons was determined in male rats. The activity of these neurons was estimated by measuring: (1) the accumulation of 3,4-dihydroxyphenylalanine (DOPA) after administration of a decarboxylase inhibitor, and (2) the concentration of 3,4-dihydroxyphenylacetic acid (DOPAC) in the nucleus accumbens and striatum, which contain the terminals of these neurons. Central administration of histamine increased both DOPA accumulation and DOPAC concentrations in the nucleus accumbens, but was without effect in the striatum. The increase in DOPAC concentrations in the nucleus accumbens occurred within 10 min and was sustained for at least 120 min. The H1 antagonist mepyramine blocked whereas the H2 antagonist zolantidine did not affect histamine-induced increases in DOPAC concentrations in the nucleus accumbens. Neither mepyramine nor zolantidine affected basal DOPAC concentrations in the nucleus accumbens. These results indicate that central administration of histamine stimulates mesolimbic DA neurons through an action at the H1 receptor, but has no effect upon the activity of nigrostriatal DA neurons.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8446183

Citation

Fleckenstein, A E., et al. "Activation of Mesolimbic Dopaminergic Neurons Following Central Administration of Histamine Is Mediated By H1 Receptors." Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 347, no. 1, 1993, pp. 50-4.
Fleckenstein AE, Lookingland KJ, Moore KE. Activation of mesolimbic dopaminergic neurons following central administration of histamine is mediated by H1 receptors. Naunyn Schmiedebergs Arch Pharmacol. 1993;347(1):50-4.
Fleckenstein, A. E., Lookingland, K. J., & Moore, K. E. (1993). Activation of mesolimbic dopaminergic neurons following central administration of histamine is mediated by H1 receptors. Naunyn-Schmiedeberg's Archives of Pharmacology, 347(1), 50-4.
Fleckenstein AE, Lookingland KJ, Moore KE. Activation of Mesolimbic Dopaminergic Neurons Following Central Administration of Histamine Is Mediated By H1 Receptors. Naunyn Schmiedebergs Arch Pharmacol. 1993;347(1):50-4. PubMed PMID: 8446183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activation of mesolimbic dopaminergic neurons following central administration of histamine is mediated by H1 receptors. AU - Fleckenstein,A E, AU - Lookingland,K J, AU - Moore,K E, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 50 EP - 4 JF - Naunyn-Schmiedeberg's archives of pharmacology JO - Naunyn Schmiedebergs Arch Pharmacol VL - 347 IS - 1 N2 - The effect of intracerebroventricular administration of histamine on the activity of mesolimbic and nigrostriatal dopaminergic (DA) neurons was determined in male rats. The activity of these neurons was estimated by measuring: (1) the accumulation of 3,4-dihydroxyphenylalanine (DOPA) after administration of a decarboxylase inhibitor, and (2) the concentration of 3,4-dihydroxyphenylacetic acid (DOPAC) in the nucleus accumbens and striatum, which contain the terminals of these neurons. Central administration of histamine increased both DOPA accumulation and DOPAC concentrations in the nucleus accumbens, but was without effect in the striatum. The increase in DOPAC concentrations in the nucleus accumbens occurred within 10 min and was sustained for at least 120 min. The H1 antagonist mepyramine blocked whereas the H2 antagonist zolantidine did not affect histamine-induced increases in DOPAC concentrations in the nucleus accumbens. Neither mepyramine nor zolantidine affected basal DOPAC concentrations in the nucleus accumbens. These results indicate that central administration of histamine stimulates mesolimbic DA neurons through an action at the H1 receptor, but has no effect upon the activity of nigrostriatal DA neurons. SN - 0028-1298 UR - https://www.unboundmedicine.com/medline/citation/8446183/Activation_of_mesolimbic_dopaminergic_neurons_following_central_administration_of_histamine_is_mediated_by_H1_receptors_ DB - PRIME DP - Unbound Medicine ER -