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Esaprazole effect on acid, peptic and alkaline secretion in duodenal ulcer patients.
Z Gastroenterol. 1993 Jan; 31(1):11-4.ZG

Abstract

To study the effect of Esaprazole, a new antiulcer drug, on acid, peptic and alkaline secretion a modified gastric acid test was performed in 18 duodenal ulcer patients. Pentagastrin was administered as bolus 30' and 75' after the beginning of the test, followed by Esaprazole 300 mg i.v. at 90'. Gastric juice was collected every 15' for determination of: total volume, volume of non parietal secretion, acid, bicarbonate and pepsin output. Serum pepsinogen group I was determined by radioimmunoassay. Esaprazole had a significant inhibitory effect on the total volume of gastric secretion and on volume of non parietal secretion. Pepsin output and serum pepsinogen group I were not affected by Esaprazole, while bicarbonate secretion was reduced. Antiulcer activity of Esaprazole seems to be due to the reduction of total volume of gastric secretion.

Authors+Show Affiliations

Dal Santo PL
Istituto di Medicina Interna Cattedra Malattie Apparato Digerente Università degli Studi di Padova, Italia.
Vianello F
No affiliation info available
Germana B
No affiliation info available
Dotto P
No affiliation info available
Laino G
No affiliation info available
Del Bianco T
No affiliation info available
Plebani M
No affiliation info available
Leandro G
No affiliation info available
Savarino V
No affiliation info available
Di Mario F
No affiliation info available

MeSH

AdultAgedAnti-Ulcer AgentsBicarbonatesDuodenal UlcerFemaleGastric AcidGastric Acidity DeterminationGastric JuiceGastric MucosaHumansInfusions, IntravenousMaleMiddle AgedPentagastrinPepsinogensPiperazines

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8447149

Citation

Dal Santo, P L., et al. "Esaprazole Effect On Acid, Peptic and Alkaline Secretion in Duodenal Ulcer Patients." Zeitschrift Fur Gastroenterologie, vol. 31, no. 1, 1993, pp. 11-4.
Dal Santo PL, Vianello F, Germana B, et al. Esaprazole effect on acid, peptic and alkaline secretion in duodenal ulcer patients. Z Gastroenterol. 1993;31(1):11-4.
Dal Santo, P. L., Vianello, F., Germana, B., Dotto, P., Laino, G., Del Bianco, T., Plebani, M., Leandro, G., Savarino, V., & Di Mario, F. (1993). Esaprazole effect on acid, peptic and alkaline secretion in duodenal ulcer patients. Zeitschrift Fur Gastroenterologie, 31(1), 11-4.
Dal Santo PL, et al. Esaprazole Effect On Acid, Peptic and Alkaline Secretion in Duodenal Ulcer Patients. Z Gastroenterol. 1993;31(1):11-4. PubMed PMID: 8447149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Esaprazole effect on acid, peptic and alkaline secretion in duodenal ulcer patients. AU - Dal Santo,P L, AU - Vianello,F, AU - Germana,B, AU - Dotto,P, AU - Laino,G, AU - Del Bianco,T, AU - Plebani,M, AU - Leandro,G, AU - Savarino,V, AU - Di Mario,F, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 11 EP - 4 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 31 IS - 1 N2 - To study the effect of Esaprazole, a new antiulcer drug, on acid, peptic and alkaline secretion a modified gastric acid test was performed in 18 duodenal ulcer patients. Pentagastrin was administered as bolus 30' and 75' after the beginning of the test, followed by Esaprazole 300 mg i.v. at 90'. Gastric juice was collected every 15' for determination of: total volume, volume of non parietal secretion, acid, bicarbonate and pepsin output. Serum pepsinogen group I was determined by radioimmunoassay. Esaprazole had a significant inhibitory effect on the total volume of gastric secretion and on volume of non parietal secretion. Pepsin output and serum pepsinogen group I were not affected by Esaprazole, while bicarbonate secretion was reduced. Antiulcer activity of Esaprazole seems to be due to the reduction of total volume of gastric secretion. SN - 0044-2771 UR - https://www.unboundmedicine.com/medline/citation/8447149/Esaprazole_effect_on_acid_peptic_and_alkaline_secretion_in_duodenal_ulcer_patients_ DB - PRIME DP - Unbound Medicine ER -