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Effects of desogestrel on carbohydrate metabolism.
Am J Obstet Gynecol. 1993 Mar; 168(3 Pt 2):1041-7.AJ

Abstract

Associated with progesterone and the synthetic progestins used in oral contraceptives is a dose-dependent impairment of carbohydrate metabolism. It is well known that in the general population hyperinsulinemia and alterations in glucose metabolism are significant risk factors for the development of cardiovascular disease. Studies that use curve analysis of glucose tolerance tests have demonstrated insulin resistance, rises in plasma insulin, and relative glucose intolerance in women using oral contraceptives. Desogestrel, a new progestin, has been demonstrated to have generally less pronounced effects on these parameters of carbohydrate metabolism.

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Publisher Full Text

Authors+Show Affiliations

Shoupe D
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles 90033.

MeSH

AnimalsBlood GlucoseCarbohydrate MetabolismContraceptives, Oral, SyntheticCoronary DiseaseDesogestrelFemaleHumansInsulinInsulin ResistanceMaleRisk Factors

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8447358

Citation

Shoupe, D. "Effects of Desogestrel On Carbohydrate Metabolism." American Journal of Obstetrics and Gynecology, vol. 168, no. 3 Pt 2, 1993, pp. 1041-7.
Shoupe D. Effects of desogestrel on carbohydrate metabolism. Am J Obstet Gynecol. 1993;168(3 Pt 2):1041-7.
Shoupe, D. (1993). Effects of desogestrel on carbohydrate metabolism. American Journal of Obstetrics and Gynecology, 168(3 Pt 2), 1041-7.
Shoupe D. Effects of Desogestrel On Carbohydrate Metabolism. Am J Obstet Gynecol. 1993;168(3 Pt 2):1041-7. PubMed PMID: 8447358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of desogestrel on carbohydrate metabolism. A1 - Shoupe,D, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez KW - Biology KW - Carbohydrate Metabolic Effects KW - Cardiovascular Effects KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Demographic Factors KW - Desogestrel KW - Diseases KW - Embolism KW - Ethinyl Estradiol KW - Ethynodiol Diacetate KW - Family Planning KW - Levonorgestrel KW - Literature Review KW - Longterm Effects KW - Metabolic Effects KW - Norethindrone KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Low-dose KW - Physiology KW - Population KW - Population Dynamics KW - Thromboembolism KW - Time Factors KW - Vascular Diseases SP - 1041 EP - 7 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 168 IS - 3 Pt 2 N2 - Associated with progesterone and the synthetic progestins used in oral contraceptives is a dose-dependent impairment of carbohydrate metabolism. It is well known that in the general population hyperinsulinemia and alterations in glucose metabolism are significant risk factors for the development of cardiovascular disease. Studies that use curve analysis of glucose tolerance tests have demonstrated insulin resistance, rises in plasma insulin, and relative glucose intolerance in women using oral contraceptives. Desogestrel, a new progestin, has been demonstrated to have generally less pronounced effects on these parameters of carbohydrate metabolism. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/8447358/Effects_of_desogestrel_on_carbohydrate_metabolism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9378(93)90335-G DB - PRIME DP - Unbound Medicine ER -