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The peroxidative metabolism of tenoxicam produces excited species.
Photochem Photobiol. 1993 Feb; 57(2):362-6.PP

Abstract

The peroxidative metabolism of the nonsteroid anti-inflammatory oxicams generates metabolites of the type expected from a dioxetane intermediate. Therefore, electronically excited metabolites may be expected. Consistent with this possibility, both direct and sensitized light emission are observed when tenoxicam is exposed to horseradish peroxidase or when added to leukocytes, where it undergoes a myeloperoxidase-catalyzed aerobic oxidation. The similarity between peroxidative metabolism with concomitant oxygen uptake and photodegradation brought about by singlet oxygen addition to the substrate is pointed out. As a whole, the results strengthen the view that electronically excited species should also be considered when analyzing the effect(s) of xenobiotics.

Authors+Show Affiliations

Department of Biochemistry, Universidade de São Paulo, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8451298

Citation

Nascimento, A L., et al. "The Peroxidative Metabolism of Tenoxicam Produces Excited Species." Photochemistry and Photobiology, vol. 57, no. 2, 1993, pp. 362-6.
Nascimento AL, Escobar JA, Cilento G. The peroxidative metabolism of tenoxicam produces excited species. Photochem Photobiol. 1993;57(2):362-6.
Nascimento, A. L., Escobar, J. A., & Cilento, G. (1993). The peroxidative metabolism of tenoxicam produces excited species. Photochemistry and Photobiology, 57(2), 362-6.
Nascimento AL, Escobar JA, Cilento G. The Peroxidative Metabolism of Tenoxicam Produces Excited Species. Photochem Photobiol. 1993;57(2):362-6. PubMed PMID: 8451298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The peroxidative metabolism of tenoxicam produces excited species. AU - Nascimento,A L, AU - Escobar,J A, AU - Cilento,G, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 362 EP - 6 JF - Photochemistry and photobiology JO - Photochem. Photobiol. VL - 57 IS - 2 N2 - The peroxidative metabolism of the nonsteroid anti-inflammatory oxicams generates metabolites of the type expected from a dioxetane intermediate. Therefore, electronically excited metabolites may be expected. Consistent with this possibility, both direct and sensitized light emission are observed when tenoxicam is exposed to horseradish peroxidase or when added to leukocytes, where it undergoes a myeloperoxidase-catalyzed aerobic oxidation. The similarity between peroxidative metabolism with concomitant oxygen uptake and photodegradation brought about by singlet oxygen addition to the substrate is pointed out. As a whole, the results strengthen the view that electronically excited species should also be considered when analyzing the effect(s) of xenobiotics. SN - 0031-8655 UR - https://www.unboundmedicine.com/medline/citation/8451298/The_peroxidative_metabolism_of_tenoxicam_produces_excited_species_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0031-8655&date=1993&volume=57&issue=2&spage=362 DB - PRIME DP - Unbound Medicine ER -