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[Synergism of midazolam and propofol in the induction of anesthesia].
Rev Esp Anestesiol Reanim. 1993 Mar-Apr; 40(2):69-71.RE

Abstract

INTRODUCTION

The purpose of this study was to determine the possible interaction of midazolam and propofol in the induction of anesthesia.

METHODS

A double-blind study of 90 ASA I-II women undergoing elective general surgery and gynecology was performed. The patients were divided into three groups of 30 patients receiving midazolam, propofol and a combination of both as the anesthesia induction agent. As a test of anesthetic induction the response to the verbal order of opening their eyes was evaluated. The dose-response curves for each group were determined by a logistic regression procedure while isobolographic analysis compared the actions of both agents separately and together.

RESULTS

The ED50 in the propofol group was 1.56 mg.kg-1 and that of the midazolam group was 0.24 mg.kg-1. In the midazolam-propofol group the ED50 of midazolam was reduced approximately a quarter (0.068 mg.kg-1) when associated to the half of the ED50 of propofol anteriorly obtained. Isobolographic analysis revealed that the conjunctive action of both drugs was synergic (p = 0.04).

CONCLUSIONS

Propofol potentiates the action of midazolam in anesthetic induction. Although this synergism also reduces with the association of thiopental-midazolam, the mechanism of action is not demonstrated as the same. Thiopental increases the affinity of the benzodiazepines for the GABA complex receptors which has not been described for propofol.

Authors+Show Affiliations

Servicio de Anestesiología-Reanimación, Hospital Universitario de Valme, Sevilla.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
English Abstract
Journal Article

Language

spa

PubMed ID

8451470

Citation

Caba, F, et al. "[Synergism of Midazolam and Propofol in the Induction of Anesthesia]." Revista Espanola De Anestesiologia Y Reanimacion, vol. 40, no. 2, 1993, pp. 69-71.
Caba F, Echevarría M, Morales R, et al. [Synergism of midazolam and propofol in the induction of anesthesia]. Rev Esp Anestesiol Reanim. 1993;40(2):69-71.
Caba, F., Echevarría, M., Morales, R., Guerrero, J. A., & Rodríguez, R. (1993). [Synergism of midazolam and propofol in the induction of anesthesia]. Revista Espanola De Anestesiologia Y Reanimacion, 40(2), 69-71.
Caba F, et al. [Synergism of Midazolam and Propofol in the Induction of Anesthesia]. Rev Esp Anestesiol Reanim. 1993 Mar-Apr;40(2):69-71. PubMed PMID: 8451470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Synergism of midazolam and propofol in the induction of anesthesia]. AU - Caba,F, AU - Echevarría,M, AU - Morales,R, AU - Guerrero,J A, AU - Rodríguez,R, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 69 EP - 71 JF - Revista espanola de anestesiologia y reanimacion JO - Rev Esp Anestesiol Reanim VL - 40 IS - 2 N2 - INTRODUCTION: The purpose of this study was to determine the possible interaction of midazolam and propofol in the induction of anesthesia. METHODS: A double-blind study of 90 ASA I-II women undergoing elective general surgery and gynecology was performed. The patients were divided into three groups of 30 patients receiving midazolam, propofol and a combination of both as the anesthesia induction agent. As a test of anesthetic induction the response to the verbal order of opening their eyes was evaluated. The dose-response curves for each group were determined by a logistic regression procedure while isobolographic analysis compared the actions of both agents separately and together. RESULTS: The ED50 in the propofol group was 1.56 mg.kg-1 and that of the midazolam group was 0.24 mg.kg-1. In the midazolam-propofol group the ED50 of midazolam was reduced approximately a quarter (0.068 mg.kg-1) when associated to the half of the ED50 of propofol anteriorly obtained. Isobolographic analysis revealed that the conjunctive action of both drugs was synergic (p = 0.04). CONCLUSIONS: Propofol potentiates the action of midazolam in anesthetic induction. Although this synergism also reduces with the association of thiopental-midazolam, the mechanism of action is not demonstrated as the same. Thiopental increases the affinity of the benzodiazepines for the GABA complex receptors which has not been described for propofol. SN - 0034-9356 UR - https://www.unboundmedicine.com/medline/citation/8451470/[Synergism_of_midazolam_and_propofol_in_the_induction_of_anesthesia]_ L2 - https://medlineplus.gov/anesthesia.html DB - PRIME DP - Unbound Medicine ER -