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The New York High-Risk Project: anhedonia, attentional deviance, and psychopathology.
Schizophr Bull. 1993; 19(1):141-53.SB

Abstract

In the New York High-Risk Project (NYHRP) we followed subjects at risk for schizophrenic or affective disorders and low-risk controls from childhood to adulthood, with the goal of identifying early predictors of later schizophrenia-related psychopathology. In this article, we focus on two potential predictors: the Physical Anhedonia Scale administered in adolescence and the Attention Deviance Index obtained in childhood. Subjects of this report are 161 members of the NYHRP's first sample (sample A), who had scores on both attention and anhedonia and had followup clinical assessments in adulthood. We used a path analysis model and several separate regression analyses to examine the relationships of the parent diagnostic groups, attentional dysfunction, and anhedonia to each other and to each of three psychopathological outcomes: schizophrenia and schizophrenia-related psychoses, major affective disorder, and social isolation in nonpsychotic subjects. Subject groups did not differ in anhedonia scores but did differ in childhood attentional dysfunction, psychosis, and social isolation, all of which are more common in subjects at risk for schizophrenia. In these subjects at risk for schizophrenia, but not in the other two groups of subjects, childhood attentional dysfunction is related to anhedonia, social isolation, and possibly nonparanoid psychosis. Anhedonia is associated with social isolation and with psychosis in females. Several other gender effects are also noted.

Authors+Show Affiliations

Dept. of Medical Genetics, New York State Psychiatric Institute, NY 10032.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8451608

Citation

Erlenmeyer-Kimling, L, et al. "The New York High-Risk Project: Anhedonia, Attentional Deviance, and Psychopathology." Schizophrenia Bulletin, vol. 19, no. 1, 1993, pp. 141-53.
Erlenmeyer-Kimling L, Cornblatt BA, Rock D, et al. The New York High-Risk Project: anhedonia, attentional deviance, and psychopathology. Schizophr Bull. 1993;19(1):141-53.
Erlenmeyer-Kimling, L., Cornblatt, B. A., Rock, D., Roberts, S., Bell, M., & West, A. (1993). The New York High-Risk Project: anhedonia, attentional deviance, and psychopathology. Schizophrenia Bulletin, 19(1), 141-53.
Erlenmeyer-Kimling L, et al. The New York High-Risk Project: Anhedonia, Attentional Deviance, and Psychopathology. Schizophr Bull. 1993;19(1):141-53. PubMed PMID: 8451608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The New York High-Risk Project: anhedonia, attentional deviance, and psychopathology. AU - Erlenmeyer-Kimling,L, AU - Cornblatt,B A, AU - Rock,D, AU - Roberts,S, AU - Bell,M, AU - West,A, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 141 EP - 53 JF - Schizophrenia bulletin JO - Schizophr Bull VL - 19 IS - 1 N2 - In the New York High-Risk Project (NYHRP) we followed subjects at risk for schizophrenic or affective disorders and low-risk controls from childhood to adulthood, with the goal of identifying early predictors of later schizophrenia-related psychopathology. In this article, we focus on two potential predictors: the Physical Anhedonia Scale administered in adolescence and the Attention Deviance Index obtained in childhood. Subjects of this report are 161 members of the NYHRP's first sample (sample A), who had scores on both attention and anhedonia and had followup clinical assessments in adulthood. We used a path analysis model and several separate regression analyses to examine the relationships of the parent diagnostic groups, attentional dysfunction, and anhedonia to each other and to each of three psychopathological outcomes: schizophrenia and schizophrenia-related psychoses, major affective disorder, and social isolation in nonpsychotic subjects. Subject groups did not differ in anhedonia scores but did differ in childhood attentional dysfunction, psychosis, and social isolation, all of which are more common in subjects at risk for schizophrenia. In these subjects at risk for schizophrenia, but not in the other two groups of subjects, childhood attentional dysfunction is related to anhedonia, social isolation, and possibly nonparanoid psychosis. Anhedonia is associated with social isolation and with psychosis in females. Several other gender effects are also noted. SN - 0586-7614 UR - https://www.unboundmedicine.com/medline/citation/8451608/The_New_York_High_Risk_Project:_anhedonia_attentional_deviance_and_psychopathology_ L2 - https://academic.oup.com/schizophreniabulletin/article-lookup/doi/10.1093/schbul/19.1.141 DB - PRIME DP - Unbound Medicine ER -