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Generation of electronically excited triplet species at the cellular level: a potential source of genotoxicity.
Toxicol Lett 1993; 67(1-3):17-28TL

Abstract

Selected enzymatic systems can efficiently produce a product in the electronically excited triplet state. Earlier, only the formation of electronically excited singlet species was known. The formation of triplet species has been demonstrated with both normal substrates/metabolites and with xenobiotics, even at the cellular level. Triplet excited species have intrinsically much longer lifetimes than excited singlets, whereby they can be potentially important agents for normal and/or deleterious processes, including mutagenesis. Enzymically generated triplet species can damage DNA, even when protein coated, as in the case of the lambda-phage of Escherichia coli. Some evidence of damage by triplet species has also been reported for intact cells. Triplet excited species may produce their effects through type I and/or type II dark photosensitization, that is, the events may be started by H abstraction and/or singlet oxygen/superoxide ion production. The induction of lipid peroxidation, with concomitant clastogenic effects, appears to be of special importance.

Authors+Show Affiliations

Department of Biochemistry, Universidade de São Paulo, Brazil.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8451758

Citation

Cilento, G, and A L. Nascimento. "Generation of Electronically Excited Triplet Species at the Cellular Level: a Potential Source of Genotoxicity." Toxicology Letters, vol. 67, no. 1-3, 1993, pp. 17-28.
Cilento G, Nascimento AL. Generation of electronically excited triplet species at the cellular level: a potential source of genotoxicity. Toxicol Lett. 1993;67(1-3):17-28.
Cilento, G., & Nascimento, A. L. (1993). Generation of electronically excited triplet species at the cellular level: a potential source of genotoxicity. Toxicology Letters, 67(1-3), pp. 17-28.
Cilento G, Nascimento AL. Generation of Electronically Excited Triplet Species at the Cellular Level: a Potential Source of Genotoxicity. Toxicol Lett. 1993;67(1-3):17-28. PubMed PMID: 8451758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Generation of electronically excited triplet species at the cellular level: a potential source of genotoxicity. AU - Cilento,G, AU - Nascimento,A L, PY - 1993/4/1/pubmed PY - 1993/4/1/medline PY - 1993/4/1/entrez SP - 17 EP - 28 JF - Toxicology letters JO - Toxicol. Lett. VL - 67 IS - 1-3 N2 - Selected enzymatic systems can efficiently produce a product in the electronically excited triplet state. Earlier, only the formation of electronically excited singlet species was known. The formation of triplet species has been demonstrated with both normal substrates/metabolites and with xenobiotics, even at the cellular level. Triplet excited species have intrinsically much longer lifetimes than excited singlets, whereby they can be potentially important agents for normal and/or deleterious processes, including mutagenesis. Enzymically generated triplet species can damage DNA, even when protein coated, as in the case of the lambda-phage of Escherichia coli. Some evidence of damage by triplet species has also been reported for intact cells. Triplet excited species may produce their effects through type I and/or type II dark photosensitization, that is, the events may be started by H abstraction and/or singlet oxygen/superoxide ion production. The induction of lipid peroxidation, with concomitant clastogenic effects, appears to be of special importance. SN - 0378-4274 UR - https://www.unboundmedicine.com/medline/citation/8451758/Generation_of_electronically_excited_triplet_species_at_the_cellular_level:_a_potential_source_of_genotoxicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-4274(93)90043-W DB - PRIME DP - Unbound Medicine ER -