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A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People's Republic of China.
Am J Epidemiol 1993; 137(2):155-65AJ

Abstract

The relation between diet and endometrial cancer was examined in a population-based case-control study conducted in Shanghai, People's Republic of China, between 1988 and 1990, involving interviews with 268 cases and 268 controls aged 18-74 years. The subjects' usual dietary intake of 63 major foods during the previous 10 years (disregarding any recent changes) was measured by means of a structured quantitative food questionnaire. Although women in the highest quartile of total caloric intake had a 2.1-fold increased risk of endometrial cancer, risk varied according to the source of calories. The highest quartiles of caloric intake from fat and protein were associated with odds ratios of 3.9 and 3.1, respectively, while calories from carbohydrates, the major contributor of total calories in this population, were not related to risk. The association of fat and protein with endometrial cancer risk was confined to foods of animal origin in the diet. After adjustment for age, body mass index (weight (kg)/height (m)2), and number of pregnancies, odds ratios were 3.5 (95% confidence interval (CI) 2.0-6.0) and 3.0 (95% CI 1.7-5.1) for women in the highest quartiles of intake of animal fat and animal protein, respectively. Food group analyses showed a similar pattern, with high consumption of meat, eggs, and fresh fish being associated with elevated risks. After adjustment for total calories, no significant association of risk was found with intake of vegetables or dark green/yellow vegetables, or with estimated carotene intake, although fruit and allium vegetables were associated with some reduction in risk. These results suggest that diets rich in animal fat and animal protein may play an important role in the etiology of endometrial cancer.

Authors+Show Affiliations

Department of Epidemiology, Shanghai Cancer Institute, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8452119

Citation

Shu, X O., et al. "A Population-based Case-control Study of Dietary Factors and Endometrial Cancer in Shanghai, People's Republic of China." American Journal of Epidemiology, vol. 137, no. 2, 1993, pp. 155-65.
Shu XO, Zheng W, Potischman N, et al. A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People's Republic of China. Am J Epidemiol. 1993;137(2):155-65.
Shu, X. O., Zheng, W., Potischman, N., Brinton, L. A., Hatch, M. C., Gao, Y. T., & Fraumeni, J. F. (1993). A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People's Republic of China. American Journal of Epidemiology, 137(2), pp. 155-65.
Shu XO, et al. A Population-based Case-control Study of Dietary Factors and Endometrial Cancer in Shanghai, People's Republic of China. Am J Epidemiol. 1993 Jan 15;137(2):155-65. PubMed PMID: 8452119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People's Republic of China. AU - Shu,X O, AU - Zheng,W, AU - Potischman,N, AU - Brinton,L A, AU - Hatch,M C, AU - Gao,Y T, AU - Fraumeni,J F,Jr PY - 1993/1/15/pubmed PY - 2001/3/28/medline PY - 1993/1/15/entrez SP - 155 EP - 65 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 137 IS - 2 N2 - The relation between diet and endometrial cancer was examined in a population-based case-control study conducted in Shanghai, People's Republic of China, between 1988 and 1990, involving interviews with 268 cases and 268 controls aged 18-74 years. The subjects' usual dietary intake of 63 major foods during the previous 10 years (disregarding any recent changes) was measured by means of a structured quantitative food questionnaire. Although women in the highest quartile of total caloric intake had a 2.1-fold increased risk of endometrial cancer, risk varied according to the source of calories. The highest quartiles of caloric intake from fat and protein were associated with odds ratios of 3.9 and 3.1, respectively, while calories from carbohydrates, the major contributor of total calories in this population, were not related to risk. The association of fat and protein with endometrial cancer risk was confined to foods of animal origin in the diet. After adjustment for age, body mass index (weight (kg)/height (m)2), and number of pregnancies, odds ratios were 3.5 (95% confidence interval (CI) 2.0-6.0) and 3.0 (95% CI 1.7-5.1) for women in the highest quartiles of intake of animal fat and animal protein, respectively. Food group analyses showed a similar pattern, with high consumption of meat, eggs, and fresh fish being associated with elevated risks. After adjustment for total calories, no significant association of risk was found with intake of vegetables or dark green/yellow vegetables, or with estimated carotene intake, although fruit and allium vegetables were associated with some reduction in risk. These results suggest that diets rich in animal fat and animal protein may play an important role in the etiology of endometrial cancer. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/8452119/A_population_based_case_control_study_of_dietary_factors_and_endometrial_cancer_in_Shanghai_People's_Republic_of_China_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a116655 DB - PRIME DP - Unbound Medicine ER -