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Characterization and hormonal control of the androgen receptor in the hamster sebaceous glands.
J Invest Dermatol. 1977 Apr; 68(4):215-20.JI

Abstract

The costovertebral organs [CVO] and seminel vesicles [SV] of the hamster exhibit high saturable androgen uptake. The physicochemcal characteristics of the cytoplasmic androgen receptor present in these tissues have been determined and compared to those obtained in rat prostate[P]. Using the synthetic androgen R 1881 [methyltrienolone] as a radioactive ligand, it has been shown that the affinity of this compound for the cytosol CVO receptor [Kd = 0.7 +/- 0.1 nM] is similar to that for the crytosol SV receptor [Kd = 2.4 +/- 0.9 nm] in hamsters and the cytosol P receptor [Kd = 0.6 +/- 0.1 nM] in rats. The hormonal specificity of binding in these tissues is restricted to androgens. Moreover, testosterone and dihydrotestosterone have the same relative binding affinity in CVO and SV compared to R 1881. Following castration, the total number of androgen sites, as measured by an exchange assay with R 1881, decreases rapidly and parallels with a fall in lipogenic activity. Administration of an androgen rapidly restores binding capacity.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

845456

Citation

Bonne, C, and J P. Raynaud. "Characterization and Hormonal Control of the Androgen Receptor in the Hamster Sebaceous Glands." The Journal of Investigative Dermatology, vol. 68, no. 4, 1977, pp. 215-20.
Bonne C, Raynaud JP. Characterization and hormonal control of the androgen receptor in the hamster sebaceous glands. J Invest Dermatol. 1977;68(4):215-20.
Bonne, C., & Raynaud, J. P. (1977). Characterization and hormonal control of the androgen receptor in the hamster sebaceous glands. The Journal of Investigative Dermatology, 68(4), 215-20.
Bonne C, Raynaud JP. Characterization and Hormonal Control of the Androgen Receptor in the Hamster Sebaceous Glands. J Invest Dermatol. 1977;68(4):215-20. PubMed PMID: 845456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization and hormonal control of the androgen receptor in the hamster sebaceous glands. AU - Bonne,C, AU - Raynaud,J P, PY - 1977/4/1/pubmed PY - 1977/4/1/medline PY - 1977/4/1/entrez SP - 215 EP - 20 JF - The Journal of investigative dermatology JO - J. Invest. Dermatol. VL - 68 IS - 4 N2 - The costovertebral organs [CVO] and seminel vesicles [SV] of the hamster exhibit high saturable androgen uptake. The physicochemcal characteristics of the cytoplasmic androgen receptor present in these tissues have been determined and compared to those obtained in rat prostate[P]. Using the synthetic androgen R 1881 [methyltrienolone] as a radioactive ligand, it has been shown that the affinity of this compound for the cytosol CVO receptor [Kd = 0.7 +/- 0.1 nM] is similar to that for the crytosol SV receptor [Kd = 2.4 +/- 0.9 nm] in hamsters and the cytosol P receptor [Kd = 0.6 +/- 0.1 nM] in rats. The hormonal specificity of binding in these tissues is restricted to androgens. Moreover, testosterone and dihydrotestosterone have the same relative binding affinity in CVO and SV compared to R 1881. Following castration, the total number of androgen sites, as measured by an exchange assay with R 1881, decreases rapidly and parallels with a fall in lipogenic activity. Administration of an androgen rapidly restores binding capacity. SN - 0022-202X UR - https://www.unboundmedicine.com/medline/citation/845456/Characterization_and_hormonal_control_of_the_androgen_receptor_in_the_hamster_sebaceous_glands_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-202X(15)45012-2 DB - PRIME DP - Unbound Medicine ER -