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Effects of erythromycin on gastric emptying, alcohol absorption and small intestinal transit in normal subjects.
J Nucl Med. 1993 Apr; 34(4):582-8.JN

Abstract

The effects of erythromycin on gastric emptying and intragastric distribution of a mixed solid/liquid meal, alcohol absorption and small intestinal transit were examined in eight male volunteers. Each subject received, in double-blind randomized order, either erythromycin as the lactobionate (3 mg.kg-1 i.v. over 20 min) or saline immediately before the consumption of a radioisotopically labeled test meal, which consisted of 330 g minced beef and 400 ml of orange juice containing ethanol (0.5 g.kg-1 body weight) and 10 g lactulose. Erythromycin increased the rate of total stomach emptying and proximal stomach emptying of both the solid and liquid components of the meal (p < 0.001), but slowed small intestinal transit (p < 0.01). Peak blood alcohol concentrations (p < 0.01) were higher after erythromycin, with a mean increase of 40%. There was a significant inverse relationship between peak blood alcohol concentrations and the 50% emptying time for the liquid component of the meal after saline (r = -0.70, p < 0.05), but not after erythromycin (r = -0.57, p < 0.1). The total area under the venous blood alcohol concentration time curve (i.e., total absorption) was greater (p < 0.01) after erythromycin. These results suggest that: faster emptying from the proximal stomach contributes to more rapid gastric emptying induced by erythromycin, erythromycin retards small intestinal transit and that erythromycin increases the total amount of alcohol absorbed as well as the rate of alcohol absorption. These latter effects are likely to reflect more rapid delivery of alcohol to the small intestine and reduced metabolism of alcohol by the gastric mucosa.

Authors+Show Affiliations

Department of Surgery, University Hospital Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8455074

Citation

Edelbroek, M A., et al. "Effects of Erythromycin On Gastric Emptying, Alcohol Absorption and Small Intestinal Transit in Normal Subjects." Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, vol. 34, no. 4, 1993, pp. 582-8.
Edelbroek MA, Horowitz M, Wishart JM, et al. Effects of erythromycin on gastric emptying, alcohol absorption and small intestinal transit in normal subjects. J Nucl Med. 1993;34(4):582-8.
Edelbroek, M. A., Horowitz, M., Wishart, J. M., & Akkermans, L. M. (1993). Effects of erythromycin on gastric emptying, alcohol absorption and small intestinal transit in normal subjects. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 34(4), 582-8.
Edelbroek MA, et al. Effects of Erythromycin On Gastric Emptying, Alcohol Absorption and Small Intestinal Transit in Normal Subjects. J Nucl Med. 1993;34(4):582-8. PubMed PMID: 8455074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of erythromycin on gastric emptying, alcohol absorption and small intestinal transit in normal subjects. AU - Edelbroek,M A, AU - Horowitz,M, AU - Wishart,J M, AU - Akkermans,L M, PY - 1993/4/1/pubmed PY - 1993/4/1/medline PY - 1993/4/1/entrez SP - 582 EP - 8 JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine JO - J Nucl Med VL - 34 IS - 4 N2 - The effects of erythromycin on gastric emptying and intragastric distribution of a mixed solid/liquid meal, alcohol absorption and small intestinal transit were examined in eight male volunteers. Each subject received, in double-blind randomized order, either erythromycin as the lactobionate (3 mg.kg-1 i.v. over 20 min) or saline immediately before the consumption of a radioisotopically labeled test meal, which consisted of 330 g minced beef and 400 ml of orange juice containing ethanol (0.5 g.kg-1 body weight) and 10 g lactulose. Erythromycin increased the rate of total stomach emptying and proximal stomach emptying of both the solid and liquid components of the meal (p < 0.001), but slowed small intestinal transit (p < 0.01). Peak blood alcohol concentrations (p < 0.01) were higher after erythromycin, with a mean increase of 40%. There was a significant inverse relationship between peak blood alcohol concentrations and the 50% emptying time for the liquid component of the meal after saline (r = -0.70, p < 0.05), but not after erythromycin (r = -0.57, p < 0.1). The total area under the venous blood alcohol concentration time curve (i.e., total absorption) was greater (p < 0.01) after erythromycin. These results suggest that: faster emptying from the proximal stomach contributes to more rapid gastric emptying induced by erythromycin, erythromycin retards small intestinal transit and that erythromycin increases the total amount of alcohol absorbed as well as the rate of alcohol absorption. These latter effects are likely to reflect more rapid delivery of alcohol to the small intestine and reduced metabolism of alcohol by the gastric mucosa. SN - 0161-5505 UR - https://www.unboundmedicine.com/medline/citation/8455074/Effects_of_erythromycin_on_gastric_emptying_alcohol_absorption_and_small_intestinal_transit_in_normal_subjects_ L2 - http://jnm.snmjournals.org/cgi/pmidlookup?view=long&amp;pmid=8455074 DB - PRIME DP - Unbound Medicine ER -