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The Kingston Project. II. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: anthropometry.
Eur J Clin Nutr. 1993 Mar; 47(3):160-73.EJ

Abstract

Malnourished children (mean age 1.2 years) referred from public health clinics to a paediatric metabolic ward in Kingston, Jamaica, were enrolled for treatment in a community-based health care project and were randomly allocated to one of two groups. The first group was treated at home with metronidazole and then for 6 months using the standard health care provided from local clinics by community health aides. The second group was given the same drug and home treatment, but in addition received a high energy supplement of 3.31 MJ daily for 3 months. We have previously shown a significant advantage in both weight and height gain for a group given the same supplement in contrast with standard health care controls (Heikens et al., 1989, Eur. J. Clin. Nutr. 43, 145-160), and in this study test the addition of a drug treatment aimed at reducing malabsorbtion due to a possible microbial overgrowth of the small bowel in malnourished children. This paper reports anthropometric findings showing significant benefits from both the drug and nutritional treatments. Greatest gains were by the group given both treatments, but the group given the antibiotic treatment, without energy supplementation, also made better growth recovery than did controls. Only 8% of the children treated with metronidazole failed to respond to community-based intervention and were admitted to hospital, compared with 19% for the other groups (P < 0.05). These findings support targetted high-energy supplementation for the rehabilitation of moderately malnourished children receiving health clinic care, and suggest further that such programs should include antibiotic treatment directed at SBBO.

Authors+Show Affiliations

Heikens GT
Tropical Metabolism Research Unit, University of the West Indies, Kingston, Jamaica.
Schofield WN
No affiliation info available
Dawson S
No affiliation info available

MeSH

Analysis of VarianceAnthropometryChild, PreschoolFood, FortifiedHome Care ServicesHospitalizationHumansInfantInfant Nutrition DisordersJamaicaMetronidazole

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8458314

Citation

Heikens, G T., et al. "The Kingston Project. II. the Effects of High Energy Supplement and Metronidazole On Malnourished Children Rehabilitated in the Community: Anthropometry." European Journal of Clinical Nutrition, vol. 47, no. 3, 1993, pp. 160-73.
Heikens GT, Schofield WN, Dawson S. The Kingston Project. II. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: anthropometry. Eur J Clin Nutr. 1993;47(3):160-73.
Heikens, G. T., Schofield, W. N., & Dawson, S. (1993). The Kingston Project. II. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: anthropometry. European Journal of Clinical Nutrition, 47(3), 160-73.
Heikens GT, Schofield WN, Dawson S. The Kingston Project. II. the Effects of High Energy Supplement and Metronidazole On Malnourished Children Rehabilitated in the Community: Anthropometry. Eur J Clin Nutr. 1993;47(3):160-73. PubMed PMID: 8458314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Kingston Project. II. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: anthropometry. AU - Heikens,G T, AU - Schofield,W N, AU - Dawson,S, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez KW - Age Factors KW - Americas KW - Anthropometry KW - Antibiotics KW - Biology KW - Body Height--changes KW - Body Weight--changes KW - Caribbean KW - Child KW - Child Development KW - Comparative Studies KW - Cross Sectional Analysis KW - Delivery Of Health Care KW - Demographic Factors KW - Developing Countries KW - Diseases KW - Drugs KW - Food Supplementation KW - Growth KW - Health KW - Health Services KW - Jamaica KW - Longitudinal Studies KW - Malnutrition KW - Measurement KW - North America KW - Nutrition Disorders KW - Nutrition Programs KW - Physiology KW - Population KW - Population Characteristics KW - Primary Health Care KW - Research Methodology KW - Research Report KW - Studies KW - Treatment KW - Urban Population KW - Youth SP - 160 EP - 73 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 47 IS - 3 N2 - Malnourished children (mean age 1.2 years) referred from public health clinics to a paediatric metabolic ward in Kingston, Jamaica, were enrolled for treatment in a community-based health care project and were randomly allocated to one of two groups. The first group was treated at home with metronidazole and then for 6 months using the standard health care provided from local clinics by community health aides. The second group was given the same drug and home treatment, but in addition received a high energy supplement of 3.31 MJ daily for 3 months. We have previously shown a significant advantage in both weight and height gain for a group given the same supplement in contrast with standard health care controls (Heikens et al., 1989, Eur. J. Clin. Nutr. 43, 145-160), and in this study test the addition of a drug treatment aimed at reducing malabsorbtion due to a possible microbial overgrowth of the small bowel in malnourished children. This paper reports anthropometric findings showing significant benefits from both the drug and nutritional treatments. Greatest gains were by the group given both treatments, but the group given the antibiotic treatment, without energy supplementation, also made better growth recovery than did controls. Only 8% of the children treated with metronidazole failed to respond to community-based intervention and were admitted to hospital, compared with 19% for the other groups (P < 0.05). These findings support targetted high-energy supplementation for the rehabilitation of moderately malnourished children receiving health clinic care, and suggest further that such programs should include antibiotic treatment directed at SBBO. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/8458314/The_Kingston_Project__II__The_effects_of_high_energy_supplement_and_metronidazole_on_malnourished_children_rehabilitated_in_the_community:_anthropometry_ L2 - https://medlineplus.gov/infantandnewbornnutrition.html DB - PRIME DP - Unbound Medicine ER -