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On line continuous monitoring of subcutaneous tissue glucose is feasible by combining portable glucosensor with microdialysis.

Abstract

A new method for continuous measurement of subcutaneous tissue glucose content is introduced: by combining the microdialysis technique with a wearable amperometric glucose sensor, a device for continuous glucose measurement in the subcutaneous tissue was obtained. This device was applied to healthy volunteers (n = 10) over the period of an oral glucose load and to type I diabetic patients (n = 10) under the conditions of daily life. Glucose profiles in both healthy and diabetic persons were followed in the subcutaneous tissue up to 27 hours. This technique will certainly open new perspectives of monitoring and treating diabetic patients.

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  • Authors

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    MeSH

    Biosensing Techniques
    Blood Glucose
    Diabetes Mellitus, Type 1
    Dialysis
    Glucose
    Humans
    Monitoring, Physiologic

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8458608

    Citation

    TY - JOUR T1 - On line continuous monitoring of subcutaneous tissue glucose is feasible by combining portable glucosensor with microdialysis. AU - Pfeiffer,E F, AU - Meyerhoff,C, AU - Bischof,F, AU - Keck,F S, AU - Kerner,W, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 121 EP - 4 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme JO - Horm. Metab. Res. VL - 25 IS - 2 N2 - A new method for continuous measurement of subcutaneous tissue glucose content is introduced: by combining the microdialysis technique with a wearable amperometric glucose sensor, a device for continuous glucose measurement in the subcutaneous tissue was obtained. This device was applied to healthy volunteers (n = 10) over the period of an oral glucose load and to type I diabetic patients (n = 10) under the conditions of daily life. Glucose profiles in both healthy and diabetic persons were followed in the subcutaneous tissue up to 27 hours. This technique will certainly open new perspectives of monitoring and treating diabetic patients. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/8458608/abstract/On_line_continuous_monitoring_of_subcutaneous_tissue_glucose_is_feasible_by_combining_portable_glucosensor_with_microdialysis_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1002057 ER -