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Do delayed childbearers face increased risks of adverse pregnancy outcomes after the first birth?
Obstet Gynecol. 1993 Apr; 81(4):512-6.OG

Abstract

OBJECTIVE

To investigate whether the age-related risk of adverse pregnancy outcomes in the first birth persisted in the second birth, before and after adjusting for the influence of an adverse pregnancy outcome in the first birth and for other possible confounders.

METHODS

Prospectively collected longitudinal data from the Swedish Medical Birth Registry (n = 210,735 women) were analyzed to contrast the effects of maternal age at the first birth on the risk of adverse pregnancy outcomes in the first and second successive births.

RESULTS

Rates of adverse pregnancy outcomes were substantially higher in first than in second births. Compared with women aged 20-24, women aged 30-34 years had significantly higher odds ratios (ORs) of late fetal death (OR 1.4) and early neonatal death (OR 1.4) for the first but not for second births; women aged 35+ had a significantly higher OR of late fetal death (OR 2.2) for the first but not for second births. Women over 35 also had a significantly higher OR of early neonatal death for the first birth (OR 2.8) and less of an increase for second births (OR 1.8), a higher OR of low birth weight (LBW) for the first (OR 1.5) and second births (OR 1.6), and a higher OR of preterm birth for the first (OR 1.4) and second births (OR 1.7). Despite the strong tendency to repeat an adverse pregnancy outcome in second births, the age-related ORs did not change with adjustment for the previous pregnancy outcome.

CONCLUSION

Women aged 30+ at their first births have increased risks of adverse pregnancy outcomes in first births. However, second births showed no age-related increase in late fetal death and a smaller increase in early neonatal death. Increased risks for LBW and preterm birth were similar for first and second births of delayed childbearers.

Authors+Show Affiliations

Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8459958

Citation

Cnattingius, S, et al. "Do Delayed Childbearers Face Increased Risks of Adverse Pregnancy Outcomes After the First Birth?" Obstetrics and Gynecology, vol. 81, no. 4, 1993, pp. 512-6.
Cnattingius S, Berendes HW, Forman MR. Do delayed childbearers face increased risks of adverse pregnancy outcomes after the first birth? Obstet Gynecol. 1993;81(4):512-6.
Cnattingius, S., Berendes, H. W., & Forman, M. R. (1993). Do delayed childbearers face increased risks of adverse pregnancy outcomes after the first birth? Obstetrics and Gynecology, 81(4), 512-6.
Cnattingius S, Berendes HW, Forman MR. Do Delayed Childbearers Face Increased Risks of Adverse Pregnancy Outcomes After the First Birth. Obstet Gynecol. 1993;81(4):512-6. PubMed PMID: 8459958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do delayed childbearers face increased risks of adverse pregnancy outcomes after the first birth? AU - Cnattingius,S, AU - Berendes,H W, AU - Forman,M R, PY - 1993/4/1/pubmed PY - 1993/4/1/medline PY - 1993/4/1/entrez SP - 512 EP - 6 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 81 IS - 4 N2 - OBJECTIVE: To investigate whether the age-related risk of adverse pregnancy outcomes in the first birth persisted in the second birth, before and after adjusting for the influence of an adverse pregnancy outcome in the first birth and for other possible confounders. METHODS: Prospectively collected longitudinal data from the Swedish Medical Birth Registry (n = 210,735 women) were analyzed to contrast the effects of maternal age at the first birth on the risk of adverse pregnancy outcomes in the first and second successive births. RESULTS: Rates of adverse pregnancy outcomes were substantially higher in first than in second births. Compared with women aged 20-24, women aged 30-34 years had significantly higher odds ratios (ORs) of late fetal death (OR 1.4) and early neonatal death (OR 1.4) for the first but not for second births; women aged 35+ had a significantly higher OR of late fetal death (OR 2.2) for the first but not for second births. Women over 35 also had a significantly higher OR of early neonatal death for the first birth (OR 2.8) and less of an increase for second births (OR 1.8), a higher OR of low birth weight (LBW) for the first (OR 1.5) and second births (OR 1.6), and a higher OR of preterm birth for the first (OR 1.4) and second births (OR 1.7). Despite the strong tendency to repeat an adverse pregnancy outcome in second births, the age-related ORs did not change with adjustment for the previous pregnancy outcome. CONCLUSION: Women aged 30+ at their first births have increased risks of adverse pregnancy outcomes in first births. However, second births showed no age-related increase in late fetal death and a smaller increase in early neonatal death. Increased risks for LBW and preterm birth were similar for first and second births of delayed childbearers. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/8459958/Do_delayed_childbearers_face_increased_risks_of_adverse_pregnancy_outcomes_after_the_first_birth L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8459958.ui DB - PRIME DP - Unbound Medicine ER -