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Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older.

Abstract

Subjects with clinically diagnosed senile dementia of the Alzheimer type (n = 37) and healthy controls (n = 5) were assessed clinically until death. Postmortem examination of the brain was performed at age 80 years or older. The brains of all of the group with dementia (except one that was found to have a non-Alzheimer dementia) had substantial densities of neocortical senile plaques regardless of dementia severity; the control brains had very few senile plaques. In those subjects with Alzheimer's disease, moderate correlations were found between dementia duration and severity (cognitive portion of the Blessed Dementia Scale and the Sum of Boxes from the Clinical Dementia Rating) and certain neuropathological lesions, both gross and microscopic. Densities of neocortical neurofibrillary tangles were related to degree of dementia; densities of neocortical senile plaques were unrelated. We conclude that (1) neocortical senile plaque densities differentiate very old subjects with Alzheimer's disease from nondemented controls, but there is a need for more postmortem studies of older persons who are free of dementia; and (2) among the microscopic lesions studied, densities of neocortical neurofibrillary tangles were most closely related to the degree and duration of dementia.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Washington University School of Medicine, St Louis, Mo. 63110.

    , , ,

    Source

    Archives of neurology 50:4 1993 Apr pg 349-58

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Brain
    Dementia
    Female
    Humans
    Male
    Neurofibrillary Tangles

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    8460956

    Citation

    Berg, L, et al. "Neuropathological Indexes of Alzheimer's Disease in Demented and Nondemented Persons Aged 80 Years and Older." Archives of Neurology, vol. 50, no. 4, 1993, pp. 349-58.
    Berg L, McKeel DW, Miller JP, et al. Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older. Arch Neurol. 1993;50(4):349-58.
    Berg, L., McKeel, D. W., Miller, J. P., Baty, J., & Morris, J. C. (1993). Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older. Archives of Neurology, 50(4), pp. 349-58.
    Berg L, et al. Neuropathological Indexes of Alzheimer's Disease in Demented and Nondemented Persons Aged 80 Years and Older. Arch Neurol. 1993;50(4):349-58. PubMed PMID: 8460956.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older. AU - Berg,L, AU - McKeel,D W,Jr AU - Miller,J P, AU - Baty,J, AU - Morris,J C, PY - 1993/4/1/pubmed PY - 2001/3/28/medline PY - 1993/4/1/entrez SP - 349 EP - 58 JF - Archives of neurology JO - Arch. Neurol. VL - 50 IS - 4 N2 - Subjects with clinically diagnosed senile dementia of the Alzheimer type (n = 37) and healthy controls (n = 5) were assessed clinically until death. Postmortem examination of the brain was performed at age 80 years or older. The brains of all of the group with dementia (except one that was found to have a non-Alzheimer dementia) had substantial densities of neocortical senile plaques regardless of dementia severity; the control brains had very few senile plaques. In those subjects with Alzheimer's disease, moderate correlations were found between dementia duration and severity (cognitive portion of the Blessed Dementia Scale and the Sum of Boxes from the Clinical Dementia Rating) and certain neuropathological lesions, both gross and microscopic. Densities of neocortical neurofibrillary tangles were related to degree of dementia; densities of neocortical senile plaques were unrelated. We conclude that (1) neocortical senile plaque densities differentiate very old subjects with Alzheimer's disease from nondemented controls, but there is a need for more postmortem studies of older persons who are free of dementia; and (2) among the microscopic lesions studied, densities of neocortical neurofibrillary tangles were most closely related to the degree and duration of dementia. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/8460956/Neuropathological_indexes_of_Alzheimer's_disease_in_demented_and_nondemented_persons_aged_80_years_and_older_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/50/pg/349 DB - PRIME DP - Unbound Medicine ER -