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Screening for thyroid disorders in a working population.
Clin Investig. 1993 Feb; 71(2):126-31.CI

Abstract

Subclinical thyroid disorders have received increasing attention in recent years due to refined laboratory methods and a stronger emphasis on the role of preventive medicine. We performed a screening for thyroid-stimulating hormone (TSH) on 6884 persons in a working population. In cases in which TSH was not within the normal range we also measured the levels of triiodothyronine (T3), thyroxine (T4), and thyroxine-binding globulin (TBG). All persons who did not present with exclusion criteria or other nonthyroidal illnesses (n = 59) and the controls (n = 39) were submitted to thyrotropin-releasing hormone (TRH)-testing. Additionally, sonography of the thyroid was performed on 120 persons (59 subjects with abnormal hormone levels and 61 controls) to determine thyroid size and rule out morphological abnormalities. Based on the TRH test and T3, T4, and TBG measurements we found a prevalence of 0.03% (2/6884) for overt hyperthyroidism, 0.33% (23/6884) for subclinical hypothyroidism, 0.09% (6/6884) for subclinical hypothyroidism, and 0.015% (1/6884) for overt hypothyroidism in the healthy population. In subjects with overt or subclinical hyperthyroidism the prevalence of goiters (thyroid volume > 18 ml in women, > 25 ml in men) was 28%. Of this group 48% had structural abnormalities. All persons with goiters and/or structural abnormalities were over 35 years of age. Among the euthyroid, 20% had thyroid enlargement, and the same proportion presented with structural abnormalities. There were no differences between the two age groups. In the group with overt/subclinical hypothyroidism 47% presented with structural abnormalities of the thyroid; however, none presented with thyroid enlargement. Thyroid nodules were found only in older persons (> 35 years) with euthyroidism or hypothyroidism.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Zentrum der Inneren Medizin, Abteilung für Endokrinologie, Johann-Wolfgang Goethe Universität Frankfurt/Main.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8461623

Citation

Schaaf, L, et al. "Screening for Thyroid Disorders in a Working Population." The Clinical Investigator, vol. 71, no. 2, 1993, pp. 126-31.
Schaaf L, Pohl T, Schmidt R, et al. Screening for thyroid disorders in a working population. Clin Investig. 1993;71(2):126-31.
Schaaf, L., Pohl, T., Schmidt, R., Vardali, I., Teuber, J., Schlote-Sauter, B., Nowotny, B., Schiebeler, H., Zober, A., & Usadel, K. H. (1993). Screening for thyroid disorders in a working population. The Clinical Investigator, 71(2), 126-31.
Schaaf L, et al. Screening for Thyroid Disorders in a Working Population. Clin Investig. 1993;71(2):126-31. PubMed PMID: 8461623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening for thyroid disorders in a working population. AU - Schaaf,L, AU - Pohl,T, AU - Schmidt,R, AU - Vardali,I, AU - Teuber,J, AU - Schlote-Sauter,B, AU - Nowotny,B, AU - Schiebeler,H, AU - Zober,A, AU - Usadel,K H, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 126 EP - 31 JF - The Clinical investigator JO - Clin Investig VL - 71 IS - 2 N2 - Subclinical thyroid disorders have received increasing attention in recent years due to refined laboratory methods and a stronger emphasis on the role of preventive medicine. We performed a screening for thyroid-stimulating hormone (TSH) on 6884 persons in a working population. In cases in which TSH was not within the normal range we also measured the levels of triiodothyronine (T3), thyroxine (T4), and thyroxine-binding globulin (TBG). All persons who did not present with exclusion criteria or other nonthyroidal illnesses (n = 59) and the controls (n = 39) were submitted to thyrotropin-releasing hormone (TRH)-testing. Additionally, sonography of the thyroid was performed on 120 persons (59 subjects with abnormal hormone levels and 61 controls) to determine thyroid size and rule out morphological abnormalities. Based on the TRH test and T3, T4, and TBG measurements we found a prevalence of 0.03% (2/6884) for overt hyperthyroidism, 0.33% (23/6884) for subclinical hypothyroidism, 0.09% (6/6884) for subclinical hypothyroidism, and 0.015% (1/6884) for overt hypothyroidism in the healthy population. In subjects with overt or subclinical hyperthyroidism the prevalence of goiters (thyroid volume > 18 ml in women, > 25 ml in men) was 28%. Of this group 48% had structural abnormalities. All persons with goiters and/or structural abnormalities were over 35 years of age. Among the euthyroid, 20% had thyroid enlargement, and the same proportion presented with structural abnormalities. There were no differences between the two age groups. In the group with overt/subclinical hypothyroidism 47% presented with structural abnormalities of the thyroid; however, none presented with thyroid enlargement. Thyroid nodules were found only in older persons (> 35 years) with euthyroidism or hypothyroidism.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0941-0198 UR - https://www.unboundmedicine.com/medline/citation/8461623/Screening_for_thyroid_disorders_in_a_working_population_ DB - PRIME DP - Unbound Medicine ER -