Tags

Type your tag names separated by a space and hit enter

Effect of the infusion of OKY-046, a thromboxane A2 synthase inhibitor, on urinary metabolites of prostacyclin and thromboxane A2 in healthy human subjects.
Thromb Haemost 1993; 69(3):276-81TH

Abstract

The influence of OKY-046, a selective thromboxane synthase inhibitor, on prostanoid formation in healthy human subjects was studied. Vehicle (5% glucose solution) or OKY-046 in 5% glucose solution at 15 micrograms kg-1 min-1 was intravenously administered to five male healthy volunteers for 6 h. Platelet aggregation and thromboxane B2 (TXB2) formation induced by collagen and arachidonic acid were suppressed by the infusion of OKY-046, while both were not affected by the infusion of vehicle. Urinary excretion of 11-dehydro-thromboxane B2, one of major urinary metabolites of thromboxane A2 (TXA2) was decreased by the infusion of OKY-046, while that of 2,3-dinor-6-keto-prostaglandin F1 alpha, one of major urinary metabolites of prostacyclin (PGI2) was increased. The present study demonstrated that the infusion of OKY-046 improved the balance of TXA2/PGI2 into antithrombotic state in healthy subjects. It was also suggested that endogenously produced (probably platelet-derived) endoperoxides could be redirected into prostacyclin in vivo.

Authors+Show Affiliations

Second Department of Internal Medicine, Chiba University Medical School, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8470052

Citation

Morio, H, et al. "Effect of the Infusion of OKY-046, a Thromboxane A2 Synthase Inhibitor, On Urinary Metabolites of Prostacyclin and Thromboxane A2 in Healthy Human Subjects." Thrombosis and Haemostasis, vol. 69, no. 3, 1993, pp. 276-81.
Morio H, Hirai A, Terano T, et al. Effect of the infusion of OKY-046, a thromboxane A2 synthase inhibitor, on urinary metabolites of prostacyclin and thromboxane A2 in healthy human subjects. Thromb Haemost. 1993;69(3):276-81.
Morio, H., Hirai, A., Terano, T., Tamura, Y., & Yoshida, S. (1993). Effect of the infusion of OKY-046, a thromboxane A2 synthase inhibitor, on urinary metabolites of prostacyclin and thromboxane A2 in healthy human subjects. Thrombosis and Haemostasis, 69(3), pp. 276-81.
Morio H, et al. Effect of the Infusion of OKY-046, a Thromboxane A2 Synthase Inhibitor, On Urinary Metabolites of Prostacyclin and Thromboxane A2 in Healthy Human Subjects. Thromb Haemost. 1993 Mar 1;69(3):276-81. PubMed PMID: 8470052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of the infusion of OKY-046, a thromboxane A2 synthase inhibitor, on urinary metabolites of prostacyclin and thromboxane A2 in healthy human subjects. AU - Morio,H, AU - Hirai,A, AU - Terano,T, AU - Tamura,Y, AU - Yoshida,S, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 276 EP - 81 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 69 IS - 3 N2 - The influence of OKY-046, a selective thromboxane synthase inhibitor, on prostanoid formation in healthy human subjects was studied. Vehicle (5% glucose solution) or OKY-046 in 5% glucose solution at 15 micrograms kg-1 min-1 was intravenously administered to five male healthy volunteers for 6 h. Platelet aggregation and thromboxane B2 (TXB2) formation induced by collagen and arachidonic acid were suppressed by the infusion of OKY-046, while both were not affected by the infusion of vehicle. Urinary excretion of 11-dehydro-thromboxane B2, one of major urinary metabolites of thromboxane A2 (TXA2) was decreased by the infusion of OKY-046, while that of 2,3-dinor-6-keto-prostaglandin F1 alpha, one of major urinary metabolites of prostacyclin (PGI2) was increased. The present study demonstrated that the infusion of OKY-046 improved the balance of TXA2/PGI2 into antithrombotic state in healthy subjects. It was also suggested that endogenously produced (probably platelet-derived) endoperoxides could be redirected into prostacyclin in vivo. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/8470052/Effect_of_the_infusion_of_OKY_046_a_thromboxane_A2_synthase_inhibitor_on_urinary_metabolites_of_prostacyclin_and_thromboxane_A2_in_healthy_human_subjects_ DB - PRIME DP - Unbound Medicine ER -