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Free radicals as mediators of tissue injury and disease.
Crit Rev Toxicol 1993; 23(1):21-48CR

Abstract

A radical is any molecule that contains one or more unpaired electrons. Radicals are normally generated in many metabolic pathways. Some of these radicals can exist in a free form and subsequently interact with various tissue components resulting in dysfunction. The potential role of oxygen- or xenobiotic-derived free radicals in the pathology of several human diseases has stimulated extensive research linking the toxicity of numerous xenobiotics and disease processes to a free radical mechanism. However, because free radical-mediated changes are pervasive and often poorly understood, the question of whether such species are a major cause of tissue injury and human disease remains equivocal. This review discusses cellular sources of various radical species and their reactions with vital cellular constituents. Examples of purported free radical-mediated disorders are discussed in detail to provide insights into the controversy over whether free radicals are important mediators of tissue injury.

Authors+Show Affiliations

Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

8471159

Citation

Kehrer, J P.. "Free Radicals as Mediators of Tissue Injury and Disease." Critical Reviews in Toxicology, vol. 23, no. 1, 1993, pp. 21-48.
Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol. 1993;23(1):21-48.
Kehrer, J. P. (1993). Free radicals as mediators of tissue injury and disease. Critical Reviews in Toxicology, 23(1), pp. 21-48.
Kehrer JP. Free Radicals as Mediators of Tissue Injury and Disease. Crit Rev Toxicol. 1993;23(1):21-48. PubMed PMID: 8471159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Free radicals as mediators of tissue injury and disease. A1 - Kehrer,J P, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 21 EP - 48 JF - Critical reviews in toxicology JO - Crit. Rev. Toxicol. VL - 23 IS - 1 N2 - A radical is any molecule that contains one or more unpaired electrons. Radicals are normally generated in many metabolic pathways. Some of these radicals can exist in a free form and subsequently interact with various tissue components resulting in dysfunction. The potential role of oxygen- or xenobiotic-derived free radicals in the pathology of several human diseases has stimulated extensive research linking the toxicity of numerous xenobiotics and disease processes to a free radical mechanism. However, because free radical-mediated changes are pervasive and often poorly understood, the question of whether such species are a major cause of tissue injury and human disease remains equivocal. This review discusses cellular sources of various radical species and their reactions with vital cellular constituents. Examples of purported free radical-mediated disorders are discussed in detail to provide insights into the controversy over whether free radicals are important mediators of tissue injury. SN - 1040-8444 UR - https://www.unboundmedicine.com/medline/citation/8471159/Free_radicals_as_mediators_of_tissue_injury_and_disease_ L2 - http://www.tandfonline.com/doi/full/10.3109/10408449309104073 DB - PRIME DP - Unbound Medicine ER -