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Niacin. I: Dissolution profiles of sustained-release niacin products by automated and manual procedures.
J AOAC Int. 1993 Mar-Apr; 76(2):394-8.JA

Abstract

Automated and manual procedures were developed to obtain dissolution profiles of sustained-release niacin formulations. The procedures are based on the United States Pharmacopeia XXII apparatus 1 (basket) at 100 rpm with 900 mL 0.1N HCl as the dissolution medium. Filtered aliquots are read at 260 nm. No interference was found from excipients. The procedures are straightforward and will discriminate between sustained-release and regular niacin formulations.

Authors+Show Affiliations

Kirchhoefer RD
U.S. Food and Drug Administration, Division of Drug Analysis, St. Louis, MO 63101-2045.
Hipp S
No affiliation info available

MeSH

Biological AvailabilityChemistry, PharmaceuticalDelayed-Action PreparationsNiacinSolubilitySpectrophotometryTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8471864

Citation

Kirchhoefer, R D., and S Hipp. "Niacin. I: Dissolution Profiles of Sustained-release Niacin Products By Automated and Manual Procedures." Journal of AOAC International, vol. 76, no. 2, 1993, pp. 394-8.
Kirchhoefer RD, Hipp S. Niacin. I: Dissolution profiles of sustained-release niacin products by automated and manual procedures. J AOAC Int. 1993;76(2):394-8.
Kirchhoefer, R. D., & Hipp, S. (1993). Niacin. I: Dissolution profiles of sustained-release niacin products by automated and manual procedures. Journal of AOAC International, 76(2), 394-8.
Kirchhoefer RD, Hipp S. Niacin. I: Dissolution Profiles of Sustained-release Niacin Products By Automated and Manual Procedures. J AOAC Int. 1993 Mar-Apr;76(2):394-8. PubMed PMID: 8471864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Niacin. I: Dissolution profiles of sustained-release niacin products by automated and manual procedures. AU - Kirchhoefer,R D, AU - Hipp,S, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 394 EP - 8 JF - Journal of AOAC International JO - J AOAC Int VL - 76 IS - 2 N2 - Automated and manual procedures were developed to obtain dissolution profiles of sustained-release niacin formulations. The procedures are based on the United States Pharmacopeia XXII apparatus 1 (basket) at 100 rpm with 900 mL 0.1N HCl as the dissolution medium. Filtered aliquots are read at 260 nm. No interference was found from excipients. The procedures are straightforward and will discriminate between sustained-release and regular niacin formulations. SN - 1060-3271 UR - https://www.unboundmedicine.com/medline/citation/8471864/Niacin__I:_Dissolution_profiles_of_sustained_release_niacin_products_by_automated_and_manual_procedures_ DB - PRIME DP - Unbound Medicine ER -