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Comparison of lipid fatty acids on a concentration basis vs weight percentage basis in patients with and without coronary artery disease or diabetes.

Abstract

Lipid fatty acid compositions are almost always expressed on a weight percentage basis rather than as weight or molar concentrations. With the former method of calculation, each fatty acid has an effect on the composition of the other fatty acids, an interdependence that can potentially lead to inaccurate and misleading results. Here we compare the concentrations per liter and the weight percentage compositions of cholesteryl ester and phospholipid fatty acids in individuals with and without coronary artery disease as well as free fatty acid compositions in individuals with and without diabetes. A new method for quantifying lipid fatty acids is also presented. Fatty acid results expressed as concentrations and those calculated on a weight percentage basis may lead to different conclusions, because significant differences between patient groups can be lost with the latter approach. We conclude that serum concentrations of lipid fatty acids are more accurate reflections of changes in lipid fatty acids than are weight percentage calculations, and are more easily interpreted in metabolic and therapeutic terms.

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  • Authors+Show Affiliations

    ,

    Wilford Hall USAF Medical Center/SGS, Lackland Air Force Base, TX 78236-5319.

    Source

    Clinical chemistry 39:4 1993 Apr pg 659-63

    MeSH

    Adult
    Aged
    Cholesterol Esters
    Coronary Disease
    Diabetes Mellitus, Type 2
    Fatty Acids
    Humans
    Lipids
    Male
    Middle Aged
    Phospholipids
    Quality Control

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    8472362

    Citation

    Schwertner, H A., and E L. Mosser. "Comparison of Lipid Fatty Acids On a Concentration Basis Vs Weight Percentage Basis in Patients With and Without Coronary Artery Disease or Diabetes." Clinical Chemistry, vol. 39, no. 4, 1993, pp. 659-63.
    Schwertner HA, Mosser EL. Comparison of lipid fatty acids on a concentration basis vs weight percentage basis in patients with and without coronary artery disease or diabetes. Clin Chem. 1993;39(4):659-63.
    Schwertner, H. A., & Mosser, E. L. (1993). Comparison of lipid fatty acids on a concentration basis vs weight percentage basis in patients with and without coronary artery disease or diabetes. Clinical Chemistry, 39(4), pp. 659-63.
    Schwertner HA, Mosser EL. Comparison of Lipid Fatty Acids On a Concentration Basis Vs Weight Percentage Basis in Patients With and Without Coronary Artery Disease or Diabetes. Clin Chem. 1993;39(4):659-63. PubMed PMID: 8472362.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Comparison of lipid fatty acids on a concentration basis vs weight percentage basis in patients with and without coronary artery disease or diabetes. AU - Schwertner,H A, AU - Mosser,E L, PY - 1993/4/1/pubmed PY - 1993/4/1/medline PY - 1993/4/1/entrez SP - 659 EP - 63 JF - Clinical chemistry JO - Clin. Chem. VL - 39 IS - 4 N2 - Lipid fatty acid compositions are almost always expressed on a weight percentage basis rather than as weight or molar concentrations. With the former method of calculation, each fatty acid has an effect on the composition of the other fatty acids, an interdependence that can potentially lead to inaccurate and misleading results. Here we compare the concentrations per liter and the weight percentage compositions of cholesteryl ester and phospholipid fatty acids in individuals with and without coronary artery disease as well as free fatty acid compositions in individuals with and without diabetes. A new method for quantifying lipid fatty acids is also presented. Fatty acid results expressed as concentrations and those calculated on a weight percentage basis may lead to different conclusions, because significant differences between patient groups can be lost with the latter approach. We conclude that serum concentrations of lipid fatty acids are more accurate reflections of changes in lipid fatty acids than are weight percentage calculations, and are more easily interpreted in metabolic and therapeutic terms. SN - 0009-9147 UR - https://www.unboundmedicine.com/medline/citation/8472362/Comparison_of_lipid_fatty_acids_on_a_concentration_basis_vs_weight_percentage_basis_in_patients_with_and_without_coronary_artery_disease_or_diabetes_ L2 - http://www.clinchem.org/cgi/pmidlookup?view=long&pmid=8472362 DB - PRIME DP - Unbound Medicine ER -