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Sympathetic skin response and R-R interval variation in Parkinson's disease.
Mov Disord. 1993 Apr; 8(2):151-7.MD

Abstract

We investigated autonomic function in patients with idiopathic Parkinson's disease (PD) by measuring sympathetic skin response (SSR) and R-R interval variation (RRIV). Sixty-two PD patients and 62 age-matched normal subjects were recruited. Abnormal SSR was noted in nine (14.5%) PD patients, including three in Stage II, three in Stage III, and three in Stage IV, but not in Stage I patients or normal subjects. Four of these nine patients had postural hypotension. Abnormal SSR was correlated with duration of illness and impotence. In PD patients, abnormal SSR may be due to intermediolateral column dysfunction. After logarithmic transformation and age adjustment, 19 (31.6%) of 60 PD patients had abnormal RRIV during rest and deep breathing. Abnormal RRIV was not related to staging or duration of illness. Patients with constipation had significantly lower RRIV, indicating parasympathetic dysfunction. RRIV was not affected by acute or chronic L-dopa treatment. The agreement between RRIV and SSR in PD patients was poor (kappa = -0.07). It appears that abnormal SSR, but not RRIV, may be associated with more autonomic disturbances in PD patients.

Authors+Show Affiliations

Neurological Institute, Veterans General Hospital-Taipei, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8474481

Citation

Wang, S J., et al. "Sympathetic Skin Response and R-R Interval Variation in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 8, no. 2, 1993, pp. 151-7.
Wang SJ, Fuh JL, Shan DE, et al. Sympathetic skin response and R-R interval variation in Parkinson's disease. Mov Disord. 1993;8(2):151-7.
Wang, S. J., Fuh, J. L., Shan, D. E., Liao, K. K., Lin, K. P., Tsai, C. P., & Wu, Z. A. (1993). Sympathetic skin response and R-R interval variation in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 8(2), 151-7.
Wang SJ, et al. Sympathetic Skin Response and R-R Interval Variation in Parkinson's Disease. Mov Disord. 1993;8(2):151-7. PubMed PMID: 8474481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sympathetic skin response and R-R interval variation in Parkinson's disease. AU - Wang,S J, AU - Fuh,J L, AU - Shan,D E, AU - Liao,K K, AU - Lin,K P, AU - Tsai,C P, AU - Wu,Z A, PY - 1993/4/1/pubmed PY - 1993/4/1/medline PY - 1993/4/1/entrez SP - 151 EP - 7 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 8 IS - 2 N2 - We investigated autonomic function in patients with idiopathic Parkinson's disease (PD) by measuring sympathetic skin response (SSR) and R-R interval variation (RRIV). Sixty-two PD patients and 62 age-matched normal subjects were recruited. Abnormal SSR was noted in nine (14.5%) PD patients, including three in Stage II, three in Stage III, and three in Stage IV, but not in Stage I patients or normal subjects. Four of these nine patients had postural hypotension. Abnormal SSR was correlated with duration of illness and impotence. In PD patients, abnormal SSR may be due to intermediolateral column dysfunction. After logarithmic transformation and age adjustment, 19 (31.6%) of 60 PD patients had abnormal RRIV during rest and deep breathing. Abnormal RRIV was not related to staging or duration of illness. Patients with constipation had significantly lower RRIV, indicating parasympathetic dysfunction. RRIV was not affected by acute or chronic L-dopa treatment. The agreement between RRIV and SSR in PD patients was poor (kappa = -0.07). It appears that abnormal SSR, but not RRIV, may be associated with more autonomic disturbances in PD patients. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/8474481/Sympathetic_skin_response_and_R_R_interval_variation_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.870080206 DB - PRIME DP - Unbound Medicine ER -