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[Treatment of Parkinson's disease with the combination drug L-carbidopa/L-dopa. Report on a 2 years study].
Schweiz Med Wochenschr. 1977 Apr 09; 107(14):474-9.SM

Abstract

Forty patients have been treated with Sinemet (L-carbidopa/L-dopa) for a period of up to two years. The results are in agreement with those in the literature. In two-thirds of cases a good to very good improvement was obtained. The principal side effects were dyskinesia, hypotonia, and gastrointestinal and psychotic symptoms, though they seldom necessitated treatment interruption. L-carbidopa/L-dopa affords a real alternative therapy in the modern treatment of Parkinson's disease with L-dopa and a decarboxylase inhibitor. Generally the dosage range was up to a maximum of one tablet three times daily. Sinemet tablets are simple and convenient to handle for both doctor and patient. Dosage titration to therapeutic efficacy can be achieved in one week to ten days without complications, though we recommended a slower titration based on individual patient reaction and requirements.

Authors

No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

847450

Citation

Hayek, J. "[Treatment of Parkinson's Disease With the Combination Drug L-carbidopa/L-dopa. Report On a 2 Years Study]." Schweizerische Medizinische Wochenschrift, vol. 107, no. 14, 1977, pp. 474-9.
Hayek J. [Treatment of Parkinson's disease with the combination drug L-carbidopa/L-dopa. Report on a 2 years study]. Schweiz Med Wochenschr. 1977;107(14):474-9.
Hayek, J. (1977). [Treatment of Parkinson's disease with the combination drug L-carbidopa/L-dopa. Report on a 2 years study]. Schweizerische Medizinische Wochenschrift, 107(14), 474-9.
Hayek J. [Treatment of Parkinson's Disease With the Combination Drug L-carbidopa/L-dopa. Report On a 2 Years Study]. Schweiz Med Wochenschr. 1977 Apr 9;107(14):474-9. PubMed PMID: 847450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Treatment of Parkinson's disease with the combination drug L-carbidopa/L-dopa. Report on a 2 years study]. A1 - Hayek,J, PY - 1977/4/9/pubmed PY - 1977/4/9/medline PY - 1977/4/9/entrez SP - 474 EP - 9 JF - Schweizerische medizinische Wochenschrift JO - Schweiz Med Wochenschr VL - 107 IS - 14 N2 - Forty patients have been treated with Sinemet (L-carbidopa/L-dopa) for a period of up to two years. The results are in agreement with those in the literature. In two-thirds of cases a good to very good improvement was obtained. The principal side effects were dyskinesia, hypotonia, and gastrointestinal and psychotic symptoms, though they seldom necessitated treatment interruption. L-carbidopa/L-dopa affords a real alternative therapy in the modern treatment of Parkinson's disease with L-dopa and a decarboxylase inhibitor. Generally the dosage range was up to a maximum of one tablet three times daily. Sinemet tablets are simple and convenient to handle for both doctor and patient. Dosage titration to therapeutic efficacy can be achieved in one week to ten days without complications, though we recommended a slower titration based on individual patient reaction and requirements. SN - 0036-7672 UR - https://www.unboundmedicine.com/medline/citation/847450/[Treatment_of_Parkinson's_disease_with_the_combination_drug_L_carbidopa/L_dopa__Report_on_a_2_years_study]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -