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Evaluation of two iron-fortified, milk-based formulas during infancy.
Pediatrics. 1993 May; 91(5):908-14.Ped

Abstract

OBJECTIVE

Compare milk-based, iron-fortified formulas containing 7.4 and 12.7 mg/L iron and breast-feeding during the first year of life.

DESIGN

Partially randomized, double-blind trial: non-breast-fed infants randomly assigned to receive one of two coded formulas, identical except for iron content; infants discontinuing breast-feeding between 1 and 8 weeks of age randomly assigned to a formula late-start group.

SETTING

Five general community pediatric practices in Missouri, Indiana, Illinois, and Pennsylvania.

PARTICIPANTS

Sample of 347 healthy, term infants, enrolled within 1 week after birth; 172 included in statistical analyses.

OUTCOME MEASURES

Length, weight, and indicators of formula intolerance recorded at clinic visits; formula consumption, bowel movements, stool consistency, and other tolerance indicators recorded by parents on daily and weekly report forms; hemoglobin, hematocrit, and serum ferritin, iron zinc, and copper measured at 6 and 12 months.

RESULTS

No significant differences between formula-fed groups in growth, attrition, formula consumption, bowel movements, hematocrit, hemoglobin level, and serum iron, zinc, and copper levels (P > .05); first 6-month weight and length changes of the breast-fed group significantly less than in both formula-fed groups (P < .008); serum ferritin level of the formula-fed, high-iron group significantly higher than that of the low-iron and breast-fed groups (P < .008), although all groups' values were normal; no apparent differences between formula groups in formula tolerance and stool characteristics but data were not analyzed statistically.

CONCLUSIONS

Milk-based formulas containing either 7.4 or 12.7 mg/L iron support normal growth and iron status of healthy, term, normally fed infants during the first year and both are well tolerated and accepted.

Authors+Show Affiliations

Mead Johnson Research Center, Evansville, IN 47721-0001.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8474811

Citation

Bradley, C K., et al. "Evaluation of Two Iron-fortified, Milk-based Formulas During Infancy." Pediatrics, vol. 91, no. 5, 1993, pp. 908-14.
Bradley CK, Hillman L, Sherman AR, et al. Evaluation of two iron-fortified, milk-based formulas during infancy. Pediatrics. 1993;91(5):908-14.
Bradley, C. K., Hillman, L., Sherman, A. R., Leedy, D., & Cordano, A. (1993). Evaluation of two iron-fortified, milk-based formulas during infancy. Pediatrics, 91(5), 908-14.
Bradley CK, et al. Evaluation of Two Iron-fortified, Milk-based Formulas During Infancy. Pediatrics. 1993;91(5):908-14. PubMed PMID: 8474811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of two iron-fortified, milk-based formulas during infancy. AU - Bradley,C K, AU - Hillman,L, AU - Sherman,A R, AU - Leedy,D, AU - Cordano,A, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 908 EP - 14 JF - Pediatrics JO - Pediatrics VL - 91 IS - 5 N2 - OBJECTIVE: Compare milk-based, iron-fortified formulas containing 7.4 and 12.7 mg/L iron and breast-feeding during the first year of life. DESIGN: Partially randomized, double-blind trial: non-breast-fed infants randomly assigned to receive one of two coded formulas, identical except for iron content; infants discontinuing breast-feeding between 1 and 8 weeks of age randomly assigned to a formula late-start group. SETTING: Five general community pediatric practices in Missouri, Indiana, Illinois, and Pennsylvania. PARTICIPANTS: Sample of 347 healthy, term infants, enrolled within 1 week after birth; 172 included in statistical analyses. OUTCOME MEASURES: Length, weight, and indicators of formula intolerance recorded at clinic visits; formula consumption, bowel movements, stool consistency, and other tolerance indicators recorded by parents on daily and weekly report forms; hemoglobin, hematocrit, and serum ferritin, iron zinc, and copper measured at 6 and 12 months. RESULTS: No significant differences between formula-fed groups in growth, attrition, formula consumption, bowel movements, hematocrit, hemoglobin level, and serum iron, zinc, and copper levels (P > .05); first 6-month weight and length changes of the breast-fed group significantly less than in both formula-fed groups (P < .008); serum ferritin level of the formula-fed, high-iron group significantly higher than that of the low-iron and breast-fed groups (P < .008), although all groups' values were normal; no apparent differences between formula groups in formula tolerance and stool characteristics but data were not analyzed statistically. CONCLUSIONS: Milk-based formulas containing either 7.4 or 12.7 mg/L iron support normal growth and iron status of healthy, term, normally fed infants during the first year and both are well tolerated and accepted. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/8474811/Evaluation_of_two_iron_fortified_milk_based_formulas_during_infancy_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&amp;pmid=8474811 DB - PRIME DP - Unbound Medicine ER -