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Immediate changes in blood flow and oxygen metabolism of the cirrhotic liver following portacaval shunt operations.
Surg Gynecol Obstet. 1977 Apr; 144(4):499-503.SG

Abstract

In 15 patients with cirrhosis of the liver, the pressures in a systemic artery, in the inferior vena cava and the portal vein, flows in the portal vein and the hepatic artery, and oxygen content and acid-base balance in the arterial, portal and hepatic venous blood were studied during operation before and after the construction of an end-to-side portacaval shunt. Portal pressure decreased from 23 to 13 millimeters of mercury. Portal flow increased from 660 mililiters per minute to the liver to 1,300 milliliters per minute through the shunt. Hepatic arterial flow increased from 230 to 480 milliliters per minute, but this did not fully compensate for the loss of portal blood flow to the liver. Accordingly, total hepatic blood flow was reduced. There was also a decrease in the oxygen transport to the liver, but in spite of this, there was no change in the oxygen content in the hepatic vein nor any production of acid metabolites. Possible implications of these findings on the preoperative investigation of patients with portal hypertension are discussed.

Authors

Delin NA
No affiliation info available
Ekeström S
No affiliation info available
Lindahl J
No affiliation info available
Nylander G
No affiliation info available
Sundblad R
No affiliation info available

MeSH

AdolescentAdultAgedBiological TransportFemaleHepatic ArteryHumansHypertension, PortalLiver CirrhosisMaleMiddle AgedOxygen ConsumptionPortacaval Shunt, SurgicalRegional Blood Flow

Pub Type(s)

Journal Article

Language

eng

PubMed ID

847602

Citation

Delin, N A., et al. "Immediate Changes in Blood Flow and Oxygen Metabolism of the Cirrhotic Liver Following Portacaval Shunt Operations." Surgery, Gynecology & Obstetrics, vol. 144, no. 4, 1977, pp. 499-503.
Delin NA, Ekeström S, Lindahl J, et al. Immediate changes in blood flow and oxygen metabolism of the cirrhotic liver following portacaval shunt operations. Surg Gynecol Obstet. 1977;144(4):499-503.
Delin, N. A., Ekeström, S., Lindahl, J., Nylander, G., & Sundblad, R. (1977). Immediate changes in blood flow and oxygen metabolism of the cirrhotic liver following portacaval shunt operations. Surgery, Gynecology & Obstetrics, 144(4), 499-503.
Delin NA, et al. Immediate Changes in Blood Flow and Oxygen Metabolism of the Cirrhotic Liver Following Portacaval Shunt Operations. Surg Gynecol Obstet. 1977;144(4):499-503. PubMed PMID: 847602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immediate changes in blood flow and oxygen metabolism of the cirrhotic liver following portacaval shunt operations. AU - Delin,N A, AU - Ekeström,S, AU - Lindahl,J, AU - Nylander,G, AU - Sundblad,R, PY - 1977/4/1/pubmed PY - 1977/4/1/medline PY - 1977/4/1/entrez SP - 499 EP - 503 JF - Surgery, gynecology & obstetrics JO - Surg Gynecol Obstet VL - 144 IS - 4 N2 - In 15 patients with cirrhosis of the liver, the pressures in a systemic artery, in the inferior vena cava and the portal vein, flows in the portal vein and the hepatic artery, and oxygen content and acid-base balance in the arterial, portal and hepatic venous blood were studied during operation before and after the construction of an end-to-side portacaval shunt. Portal pressure decreased from 23 to 13 millimeters of mercury. Portal flow increased from 660 mililiters per minute to the liver to 1,300 milliliters per minute through the shunt. Hepatic arterial flow increased from 230 to 480 milliliters per minute, but this did not fully compensate for the loss of portal blood flow to the liver. Accordingly, total hepatic blood flow was reduced. There was also a decrease in the oxygen transport to the liver, but in spite of this, there was no change in the oxygen content in the hepatic vein nor any production of acid metabolites. Possible implications of these findings on the preoperative investigation of patients with portal hypertension are discussed. SN - 0039-6087 UR - https://www.unboundmedicine.com/medline/citation/847602/Immediate_changes_in_blood_flow_and_oxygen_metabolism_of_the_cirrhotic_liver_following_portacaval_shunt_operations_ DB - PRIME DP - Unbound Medicine ER -