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Sleep-promoting effects of growth hormone-releasing hormone in normal men.
Am J Physiol. 1993 Apr; 264(4 Pt 1):E594-8.AJ

Abstract

Growth hormone-releasing hormone (GHRH) promotes rapid-eye-movement (REM) and non-REM sleep in animals, but there is little direct evidence for a hypnogenic action of GHRH in humans. In the present study, the possible somnogenic effects of intravenous bolus injections of a dose of GHRH eliciting physiological elevations of GH secretion in healthy young men were investigated. GHRH (0.3 micrograms/kg body wt) was given in early sleep [i.e., 1st slow-wave (SW) period], late sleep (i.e., 3rd REM period), and early sleep after sleep deprivation until 0400 h (i.e., 1st SW period). In the absence of sleep deprivation, injection of GHRH in early sleep did not modify SW sleep but increased REM sleep. GHRH administration in the third REM period was followed by a marked decrease of wake and an almost 10-fold increase in SW sleep. When GHRH was administered during the first SW period after sleep deprivation until 0400 h, the duration of wake decreased. Thus GHRH has sleep-promoting effects in young adults, particularly when given at a time of decreased sleep propensity.

Authors+Show Affiliations

School of Medicine, Université Libre de Bruxelles, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8476038

Citation

Kerkhofs, M, et al. "Sleep-promoting Effects of Growth Hormone-releasing Hormone in Normal Men." The American Journal of Physiology, vol. 264, no. 4 Pt 1, 1993, pp. E594-8.
Kerkhofs M, Van Cauter E, Van Onderbergen A, et al. Sleep-promoting effects of growth hormone-releasing hormone in normal men. Am J Physiol. 1993;264(4 Pt 1):E594-8.
Kerkhofs, M., Van Cauter, E., Van Onderbergen, A., Caufriez, A., Thorner, M. O., & Copinschi, G. (1993). Sleep-promoting effects of growth hormone-releasing hormone in normal men. The American Journal of Physiology, 264(4 Pt 1), E594-8.
Kerkhofs M, et al. Sleep-promoting Effects of Growth Hormone-releasing Hormone in Normal Men. Am J Physiol. 1993;264(4 Pt 1):E594-8. PubMed PMID: 8476038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep-promoting effects of growth hormone-releasing hormone in normal men. AU - Kerkhofs,M, AU - Van Cauter,E, AU - Van Onderbergen,A, AU - Caufriez,A, AU - Thorner,M O, AU - Copinschi,G, PY - 1993/4/1/pubmed PY - 1993/4/1/medline PY - 1993/4/1/entrez SP - E594 EP - 8 JF - The American journal of physiology JO - Am J Physiol VL - 264 IS - 4 Pt 1 N2 - Growth hormone-releasing hormone (GHRH) promotes rapid-eye-movement (REM) and non-REM sleep in animals, but there is little direct evidence for a hypnogenic action of GHRH in humans. In the present study, the possible somnogenic effects of intravenous bolus injections of a dose of GHRH eliciting physiological elevations of GH secretion in healthy young men were investigated. GHRH (0.3 micrograms/kg body wt) was given in early sleep [i.e., 1st slow-wave (SW) period], late sleep (i.e., 3rd REM period), and early sleep after sleep deprivation until 0400 h (i.e., 1st SW period). In the absence of sleep deprivation, injection of GHRH in early sleep did not modify SW sleep but increased REM sleep. GHRH administration in the third REM period was followed by a marked decrease of wake and an almost 10-fold increase in SW sleep. When GHRH was administered during the first SW period after sleep deprivation until 0400 h, the duration of wake decreased. Thus GHRH has sleep-promoting effects in young adults, particularly when given at a time of decreased sleep propensity. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/8476038/Sleep_promoting_effects_of_growth_hormone_releasing_hormone_in_normal_men_ L2 - https://journals.physiology.org/doi/10.1152/ajpendo.1993.264.4.E594?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -