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Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts.
J Ethnopharmacol. 1993 Jan; 38(1):63-77.JE

Abstract

Mutagenic and antimutagenic activities of extracts and chromatographic fractions of Uncaria tomentosa bark are reported. The plant extracts and fractions show no mutagenic effect in different strains of Salmonella typhimurium with and without metabolic activation. However, the plant extracts and fractions show a protective antimutagenic effect in vitro against photomutagenesis induced by 8-methoxy-psoralen (8-MOP) plus UVA in S. typhimurium TA 102. A decoction of U. tomentosa ingested daily for 15 days by a smoker decreased the mutagenicity induced in S. typhimurium TA98 and TA100 by the subject's urine.

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Authors+Show Affiliations

Rizzi R
Departmento di Farmacologia, Chemioterapia e Tossicologia Medica, Università degli Studi di Milano, Italy.
Re F
No affiliation info available
Bianchi A
No affiliation info available
De Feo V
No affiliation info available
de Simone F
No affiliation info available
Bianchi L
No affiliation info available
Stivala LA
No affiliation info available

MeSH

AdultAnimalsAntimutagenic AgentsChloroformHumansMaleMethanolMethoxsalenMutagenicity TestsMutagensPlant ExtractsPlants, MedicinalRatsRats, Sprague-DawleySalmonella typhimuriumSmokingSolubilityUltraviolet Rays

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8479203

Citation

Rizzi, R, et al. "Mutagenic and Antimutagenic Activities of Uncaria Tomentosa and Its Extracts." Journal of Ethnopharmacology, vol. 38, no. 1, 1993, pp. 63-77.
Rizzi R, Re F, Bianchi A, et al. Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts. J Ethnopharmacol. 1993;38(1):63-77.
Rizzi, R., Re, F., Bianchi, A., De Feo, V., de Simone, F., Bianchi, L., & Stivala, L. A. (1993). Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts. Journal of Ethnopharmacology, 38(1), 63-77.
Rizzi R, et al. Mutagenic and Antimutagenic Activities of Uncaria Tomentosa and Its Extracts. J Ethnopharmacol. 1993;38(1):63-77. PubMed PMID: 8479203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts. AU - Rizzi,R, AU - Re,F, AU - Bianchi,A, AU - De Feo,V, AU - de Simone,F, AU - Bianchi,L, AU - Stivala,L A, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 63 EP - 77 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 38 IS - 1 N2 - Mutagenic and antimutagenic activities of extracts and chromatographic fractions of Uncaria tomentosa bark are reported. The plant extracts and fractions show no mutagenic effect in different strains of Salmonella typhimurium with and without metabolic activation. However, the plant extracts and fractions show a protective antimutagenic effect in vitro against photomutagenesis induced by 8-methoxy-psoralen (8-MOP) plus UVA in S. typhimurium TA 102. A decoction of U. tomentosa ingested daily for 15 days by a smoker decreased the mutagenicity induced in S. typhimurium TA98 and TA100 by the subject's urine. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/8479203/Mutagenic_and_antimutagenic_activities_of_Uncaria_tomentosa_and_its_extracts_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-8741(93)90080-O DB - PRIME DP - Unbound Medicine ER -