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Plasma acetate levels in a group of obese diabetic, obese normoglycemic, and control subjects and their relationships with other blood parameters.
Am J Gastroenterol. 1993 May; 88(5):751-5.AJ

Abstract

Acetate is a short-chain fatty acid derived from colonic fermentation of carbohydrate and dietary fiber, and from endogenous glucose and fatty acid metabolism in the liver. An impaired acetate metabolism has been reported in diabetic subjects. The aim of the study was to evaluate plasma acetate levels in a group of obese diabetic subjects, compared with obese normoglycemic subjects and normal control subjects. Eleven noninsulin-dependent diabetic patients taking oral antidiabetic drugs, eight obese normoglycemic subjects, and seven control subjects were studied. Liver, kidney, and gut functions were normal in all subjects. Blood acetate, glucose, insulin, and C-peptide were evaluated in all subjects. Acetate levels were significantly higher in the diabetic subjects than in obese normoglycemic and normal subjects. Significant correlations between HbA1c, glucose, and acetate levels, but not between acetate and C-peptide or insulin, were also observed.

Authors+Show Affiliations

Institute of Internal Medicine, Faculty of Medicine, University of Verona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8480742

Citation

Todesco, T, et al. "Plasma Acetate Levels in a Group of Obese Diabetic, Obese Normoglycemic, and Control Subjects and Their Relationships With Other Blood Parameters." The American Journal of Gastroenterology, vol. 88, no. 5, 1993, pp. 751-5.
Todesco T, Zamboni M, Armellini F, et al. Plasma acetate levels in a group of obese diabetic, obese normoglycemic, and control subjects and their relationships with other blood parameters. Am J Gastroenterol. 1993;88(5):751-5.
Todesco, T., Zamboni, M., Armellini, F., Bissoli, L., Turcato, E., Piemonte, G., Rao, A. V., Jenkins, D. J., & Bosello, O. (1993). Plasma acetate levels in a group of obese diabetic, obese normoglycemic, and control subjects and their relationships with other blood parameters. The American Journal of Gastroenterology, 88(5), 751-5.
Todesco T, et al. Plasma Acetate Levels in a Group of Obese Diabetic, Obese Normoglycemic, and Control Subjects and Their Relationships With Other Blood Parameters. Am J Gastroenterol. 1993;88(5):751-5. PubMed PMID: 8480742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma acetate levels in a group of obese diabetic, obese normoglycemic, and control subjects and their relationships with other blood parameters. AU - Todesco,T, AU - Zamboni,M, AU - Armellini,F, AU - Bissoli,L, AU - Turcato,E, AU - Piemonte,G, AU - Rao,A V, AU - Jenkins,D J, AU - Bosello,O, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 751 EP - 5 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 88 IS - 5 N2 - Acetate is a short-chain fatty acid derived from colonic fermentation of carbohydrate and dietary fiber, and from endogenous glucose and fatty acid metabolism in the liver. An impaired acetate metabolism has been reported in diabetic subjects. The aim of the study was to evaluate plasma acetate levels in a group of obese diabetic subjects, compared with obese normoglycemic subjects and normal control subjects. Eleven noninsulin-dependent diabetic patients taking oral antidiabetic drugs, eight obese normoglycemic subjects, and seven control subjects were studied. Liver, kidney, and gut functions were normal in all subjects. Blood acetate, glucose, insulin, and C-peptide were evaluated in all subjects. Acetate levels were significantly higher in the diabetic subjects than in obese normoglycemic and normal subjects. Significant correlations between HbA1c, glucose, and acetate levels, but not between acetate and C-peptide or insulin, were also observed. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/8480742/Plasma_acetate_levels_in_a_group_of_obese_diabetic_obese_normoglycemic_and_control_subjects_and_their_relationships_with_other_blood_parameters_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -