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Intestinal antibody pattern of celiac disease: occurrence in patients with normal jejunal biopsy histology.
Gastroenterology. 1993 May; 104(5):1263-72.G

Abstract

BACKGROUND

Patients with celiac disease have immunoglobulin (Ig) M antibodies and IgA antigliadin antibody in gut secretions; this pattern of intestinal immunity may be a marker of latent celiac disease. Its frequency in patients referred for jejunal biopsy has been examined.

METHODS

Serum IgG and IgA antigliadin antibody, jejunal fluid IgA and IgM antibodies to gliadin, ovalbumin and beta lactoglobulin, and jejunal fluid IgA and IgM concentrations were measured by enzyme-linked immunosorbent assay.

RESULTS

Seventeen of 19 celiac patients on normal diet and 16 of 23 on gluten-free diet had the celiaclike antibody pattern, as did 41 of 217 other patients. Jejunal biopsy histology had been classified as normal in 38 of these, with minor abnormalities in 3; however, intraepithelial lymphocyte (IEL) counts were high in 13 cases. Trial of a gluten-free diet produced clinical improvement in 6 of 7 antibody-positive patients. After extra dietary gluten, one developed subtotal villous atrophy.

CONCLUSIONS

The celiaclike intestinal antibody pattern and a high IEL count may be markers of latent gluten-sensitive enteropathy; some of these patients are clinically gluten sensitive in the absence of enteropathy.

Authors+Show Affiliations

Gastrointestinal Unit, University of Edinburgh, Scotland.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8482440

Citation

Arranz, E, and A Ferguson. "Intestinal Antibody Pattern of Celiac Disease: Occurrence in Patients With Normal Jejunal Biopsy Histology." Gastroenterology, vol. 104, no. 5, 1993, pp. 1263-72.
Arranz E, Ferguson A. Intestinal antibody pattern of celiac disease: occurrence in patients with normal jejunal biopsy histology. Gastroenterology. 1993;104(5):1263-72.
Arranz, E., & Ferguson, A. (1993). Intestinal antibody pattern of celiac disease: occurrence in patients with normal jejunal biopsy histology. Gastroenterology, 104(5), 1263-72.
Arranz E, Ferguson A. Intestinal Antibody Pattern of Celiac Disease: Occurrence in Patients With Normal Jejunal Biopsy Histology. Gastroenterology. 1993;104(5):1263-72. PubMed PMID: 8482440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal antibody pattern of celiac disease: occurrence in patients with normal jejunal biopsy histology. AU - Arranz,E, AU - Ferguson,A, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 1263 EP - 72 JF - Gastroenterology JO - Gastroenterology VL - 104 IS - 5 N2 - BACKGROUND: Patients with celiac disease have immunoglobulin (Ig) M antibodies and IgA antigliadin antibody in gut secretions; this pattern of intestinal immunity may be a marker of latent celiac disease. Its frequency in patients referred for jejunal biopsy has been examined. METHODS: Serum IgG and IgA antigliadin antibody, jejunal fluid IgA and IgM antibodies to gliadin, ovalbumin and beta lactoglobulin, and jejunal fluid IgA and IgM concentrations were measured by enzyme-linked immunosorbent assay. RESULTS: Seventeen of 19 celiac patients on normal diet and 16 of 23 on gluten-free diet had the celiaclike antibody pattern, as did 41 of 217 other patients. Jejunal biopsy histology had been classified as normal in 38 of these, with minor abnormalities in 3; however, intraepithelial lymphocyte (IEL) counts were high in 13 cases. Trial of a gluten-free diet produced clinical improvement in 6 of 7 antibody-positive patients. After extra dietary gluten, one developed subtotal villous atrophy. CONCLUSIONS: The celiaclike intestinal antibody pattern and a high IEL count may be markers of latent gluten-sensitive enteropathy; some of these patients are clinically gluten sensitive in the absence of enteropathy. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/8482440/Intestinal_antibody_pattern_of_celiac_disease:_occurrence_in_patients_with_normal_jejunal_biopsy_histology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0016-5085(93)90333-8 DB - PRIME DP - Unbound Medicine ER -