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Role of the amygdala complex in early olfactory associative learning.
Behav Neurosci. 1993 Apr; 107(2):254-63.BN

Abstract

Although olfactory associative conditioning in newborn rats produces marked structural and functional changes in the olfactory bulb, recent evidence suggests that extrabulbar circuits must be involved in storing these early memories. The present experiments examined the role of the amygdala complex on early olfactory learning. Bilateral amygdala lesions or sham lesions were performed on Postnatal Day (PN) 5. On PN6, pups were trained in a standard classical conditioning paradigm associating odor with tactile stimulation. Behavioral testing on PN7 revealed that amygdala lesions blocked odor preferences but had no effect on conditioned behavioral activation. Similar sized neocortical lesions did not impair odor preferences. Importantly, amygdala lesion effects on learned odor preferences could be reversed by extensive overtraining. These results suggest that the amygdala complex plays a critical role in modulating associative learning as early as the first postnatal week in the rat.

Authors+Show Affiliations

Department of Psychology, University of Oklahoma, Norman 73019.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8484891

Citation

Sullivan, R M., and D A. Wilson. "Role of the Amygdala Complex in Early Olfactory Associative Learning." Behavioral Neuroscience, vol. 107, no. 2, 1993, pp. 254-63.
Sullivan RM, Wilson DA. Role of the amygdala complex in early olfactory associative learning. Behav Neurosci. 1993;107(2):254-63.
Sullivan, R. M., & Wilson, D. A. (1993). Role of the amygdala complex in early olfactory associative learning. Behavioral Neuroscience, 107(2), 254-63.
Sullivan RM, Wilson DA. Role of the Amygdala Complex in Early Olfactory Associative Learning. Behav Neurosci. 1993;107(2):254-63. PubMed PMID: 8484891.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of the amygdala complex in early olfactory associative learning. AU - Sullivan,R M, AU - Wilson,D A, PY - 1993/4/1/pubmed PY - 1993/4/1/medline PY - 1993/4/1/entrez SP - 254 EP - 63 JF - Behavioral neuroscience JO - Behav Neurosci VL - 107 IS - 2 N2 - Although olfactory associative conditioning in newborn rats produces marked structural and functional changes in the olfactory bulb, recent evidence suggests that extrabulbar circuits must be involved in storing these early memories. The present experiments examined the role of the amygdala complex on early olfactory learning. Bilateral amygdala lesions or sham lesions were performed on Postnatal Day (PN) 5. On PN6, pups were trained in a standard classical conditioning paradigm associating odor with tactile stimulation. Behavioral testing on PN7 revealed that amygdala lesions blocked odor preferences but had no effect on conditioned behavioral activation. Similar sized neocortical lesions did not impair odor preferences. Importantly, amygdala lesion effects on learned odor preferences could be reversed by extensive overtraining. These results suggest that the amygdala complex plays a critical role in modulating associative learning as early as the first postnatal week in the rat. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/8484891/Role_of_the_amygdala_complex_in_early_olfactory_associative_learning_ L2 - http://content.apa.org/journals/bne/107/2/254 DB - PRIME DP - Unbound Medicine ER -