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Differential effects of triazolam and ethanol on awareness, memory, and psychomotor performance.
J Clin Psychopharmacol. 1993 Feb; 13(1):3-15.JC

Abstract

Eight normal, healthy, male volunteers each received four triazolam doses (0, 2, 4, and 8 micrograms/kg) and four ethanol doses (0, 0.25, 0.5 and 1.0 g/kg) in a double-blind, double-dummy experiment in which within-subject dose sequence was determined by a balanced Latin square design. Triazolam and ethanol produced dose-related and time-related effects on subject ratings of mood and perceived drug effects and objective measures of memory and psychomotor performance. Dose-response curves for the two drugs were not parallel, and therefore, comparisons of the two drugs were based upon comparisons of the high dose of each drug. Although the two high-dose conditions generally were not different from one another, there were differences in their relative effect sizes, which were important. The high dose of each drug produced comparable degrees of impairment on two different psychomotor tasks. Triazolam, but not ethanol, produced significant impairment on two different memory tasks. The relative effects of each drug on subject ratings of mood and perceived drug effects varied across different subject-rated measures. Only ethanol significantly increased subject ratings of alcohol strength and feeling drunk. In comparison to ethanol, triazolam tended to produce less-pronounced subject ratings of drug effect magnitude, drug liking, and estimated performance impairment. However, less-pronounced subjective effects of triazolam were not universally observed on all subject ratings. Triazolam produced greater effects on several sedative symptoms and produced comparable effects on several mood factor scales.

Authors+Show Affiliations

Substance Abuse Research Center, University of Texas Mental Sciences Institute, Houston 77030.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8486815

Citation

Roache, J D., et al. "Differential Effects of Triazolam and Ethanol On Awareness, Memory, and Psychomotor Performance." Journal of Clinical Psychopharmacology, vol. 13, no. 1, 1993, pp. 3-15.
Roache JD, Cherek DR, Bennett RH, et al. Differential effects of triazolam and ethanol on awareness, memory, and psychomotor performance. J Clin Psychopharmacol. 1993;13(1):3-15.
Roache, J. D., Cherek, D. R., Bennett, R. H., Schenkler, J. C., & Cowan, K. A. (1993). Differential effects of triazolam and ethanol on awareness, memory, and psychomotor performance. Journal of Clinical Psychopharmacology, 13(1), 3-15.
Roache JD, et al. Differential Effects of Triazolam and Ethanol On Awareness, Memory, and Psychomotor Performance. J Clin Psychopharmacol. 1993;13(1):3-15. PubMed PMID: 8486815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effects of triazolam and ethanol on awareness, memory, and psychomotor performance. AU - Roache,J D, AU - Cherek,D R, AU - Bennett,R H, AU - Schenkler,J C, AU - Cowan,K A, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 3 EP - 15 JF - Journal of clinical psychopharmacology JO - J Clin Psychopharmacol VL - 13 IS - 1 N2 - Eight normal, healthy, male volunteers each received four triazolam doses (0, 2, 4, and 8 micrograms/kg) and four ethanol doses (0, 0.25, 0.5 and 1.0 g/kg) in a double-blind, double-dummy experiment in which within-subject dose sequence was determined by a balanced Latin square design. Triazolam and ethanol produced dose-related and time-related effects on subject ratings of mood and perceived drug effects and objective measures of memory and psychomotor performance. Dose-response curves for the two drugs were not parallel, and therefore, comparisons of the two drugs were based upon comparisons of the high dose of each drug. Although the two high-dose conditions generally were not different from one another, there were differences in their relative effect sizes, which were important. The high dose of each drug produced comparable degrees of impairment on two different psychomotor tasks. Triazolam, but not ethanol, produced significant impairment on two different memory tasks. The relative effects of each drug on subject ratings of mood and perceived drug effects varied across different subject-rated measures. Only ethanol significantly increased subject ratings of alcohol strength and feeling drunk. In comparison to ethanol, triazolam tended to produce less-pronounced subject ratings of drug effect magnitude, drug liking, and estimated performance impairment. However, less-pronounced subjective effects of triazolam were not universally observed on all subject ratings. Triazolam produced greater effects on several sedative symptoms and produced comparable effects on several mood factor scales. SN - 0271-0749 UR - https://www.unboundmedicine.com/medline/citation/8486815/Differential_effects_of_triazolam_and_ethanol_on_awareness_memory_and_psychomotor_performance_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8486815.ui DB - PRIME DP - Unbound Medicine ER -