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Comparison of the effects of diets rich in stearic acid versus myristic acid and lauric acid on platelet fatty acids and excretion of thromboxane A2 and PGI2 metabolites in healthy young men.
Metabolism. 1993 Apr; 42(4):463-9.M

Abstract

The present study compared the effects of diets rich in stearic acid (C18:0) versus one high in lauric and myristic acid (C12:0, C14:0) on platelet phospholipid fatty acid levels and concentrations of urinary thromboxane B2 (TXB2) and 6-keto-PGF1 alpha, which are stable metabolites of thromboxane A2 (TXA2) and PGI2 and indicators of cardiovascular hemostasis. A diet high in dairy butter (B) was the source of C12:0 and C14:0; C18:0 was provided by diets high in cocoa butter (CB), milk chocolate (CHOC) or CB+B in a 4:1 ratio (MIX). A randomized, crossover double-blind experimental design was used. Experimental subjects (n = 15) consumed each diet for 26 days, with a 1-month washout period between each experimental period. Urine and blood were collected from each subject at the beginning and end of each dietary period. Urinary TXB2 and 6-keto-PGF1 alpha were analyzed by radioimmunoassay (RIA). There were no effects of diet on the 24-hour excretion of either metabolite or on the ratio of 6-keto-PGF1 alpha/TXB2, even though there were significant changes in the eicosanoid precursor, arachidonic acid (C20:4n-6), in platelet phospholipids. C20:4n-6 levels increased (44.8% +/- 1.0% to 47.1% +/- 1.3%; P < .05) in the phosphatidylethanolamine phospholipid subclass in subjects on the B diet and decreased in the phosphatidylcholine subclass on the CB diet (16.5% +/- 1.0% to 14.2% +/- 1.1%; P < .05) compared with baseline values.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Graduate Program in Nutrition, Pennsylvania State University, University Park 16802.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8487669

Citation

Mustad, V A., et al. "Comparison of the Effects of Diets Rich in Stearic Acid Versus Myristic Acid and Lauric Acid On Platelet Fatty Acids and Excretion of Thromboxane A2 and PGI2 Metabolites in Healthy Young Men." Metabolism: Clinical and Experimental, vol. 42, no. 4, 1993, pp. 463-9.
Mustad VA, Kris-Etherton PM, Derr J, et al. Comparison of the effects of diets rich in stearic acid versus myristic acid and lauric acid on platelet fatty acids and excretion of thromboxane A2 and PGI2 metabolites in healthy young men. Metab Clin Exp. 1993;42(4):463-9.
Mustad, V. A., Kris-Etherton, P. M., Derr, J., Reddy, C. C., & Pearson, T. A. (1993). Comparison of the effects of diets rich in stearic acid versus myristic acid and lauric acid on platelet fatty acids and excretion of thromboxane A2 and PGI2 metabolites in healthy young men. Metabolism: Clinical and Experimental, 42(4), 463-9.
Mustad VA, et al. Comparison of the Effects of Diets Rich in Stearic Acid Versus Myristic Acid and Lauric Acid On Platelet Fatty Acids and Excretion of Thromboxane A2 and PGI2 Metabolites in Healthy Young Men. Metab Clin Exp. 1993;42(4):463-9. PubMed PMID: 8487669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the effects of diets rich in stearic acid versus myristic acid and lauric acid on platelet fatty acids and excretion of thromboxane A2 and PGI2 metabolites in healthy young men. AU - Mustad,V A, AU - Kris-Etherton,P M, AU - Derr,J, AU - Reddy,C C, AU - Pearson,T A, PY - 1993/4/1/pubmed PY - 1993/4/1/medline PY - 1993/4/1/entrez SP - 463 EP - 9 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 42 IS - 4 N2 - The present study compared the effects of diets rich in stearic acid (C18:0) versus one high in lauric and myristic acid (C12:0, C14:0) on platelet phospholipid fatty acid levels and concentrations of urinary thromboxane B2 (TXB2) and 6-keto-PGF1 alpha, which are stable metabolites of thromboxane A2 (TXA2) and PGI2 and indicators of cardiovascular hemostasis. A diet high in dairy butter (B) was the source of C12:0 and C14:0; C18:0 was provided by diets high in cocoa butter (CB), milk chocolate (CHOC) or CB+B in a 4:1 ratio (MIX). A randomized, crossover double-blind experimental design was used. Experimental subjects (n = 15) consumed each diet for 26 days, with a 1-month washout period between each experimental period. Urine and blood were collected from each subject at the beginning and end of each dietary period. Urinary TXB2 and 6-keto-PGF1 alpha were analyzed by radioimmunoassay (RIA). There were no effects of diet on the 24-hour excretion of either metabolite or on the ratio of 6-keto-PGF1 alpha/TXB2, even though there were significant changes in the eicosanoid precursor, arachidonic acid (C20:4n-6), in platelet phospholipids. C20:4n-6 levels increased (44.8% +/- 1.0% to 47.1% +/- 1.3%; P < .05) in the phosphatidylethanolamine phospholipid subclass in subjects on the B diet and decreased in the phosphatidylcholine subclass on the CB diet (16.5% +/- 1.0% to 14.2% +/- 1.1%; P < .05) compared with baseline values.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/8487669/Comparison_of_the_effects_of_diets_rich_in_stearic_acid_versus_myristic_acid_and_lauric_acid_on_platelet_fatty_acids_and_excretion_of_thromboxane_A2_and_PGI2_metabolites_in_healthy_young_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0026-0495(93)90104-V DB - PRIME DP - Unbound Medicine ER -