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Adolescent blood pressure in a cohort study of sickle cell disease.
Arch Intern Med. 1993 May 24; 153(10):1233-6.AI

Abstract

BACKGROUND

Previous studies on low blood pressure in patients with homozygous sickle cell (SS) disease have sought new hypotheses on the mechanism of low blood pressure but have not analyzed the role of known determinants such as weight.

METHODS

Blood pressure has been measured by an automated oscillometric method in 220 patients with SS disease, 144 with sickle cell-hemoglobin C disease (both groups aged, 9.5 to 18.5 years) and 122 control subjects with a normal hemoglobin genotype (aged 16.0 to 18.5 years) participating in a cohort study from birth.

RESULTS

Significant age-related increases in systolic and mean arterial pressure occurred in sickle cell-hemoglobin C disease but not in SS disease. Further analyses were confined to a subgroup of 51 patients with SS, 41 patients with sickle cell-hemoglobin C, and 97 subjects with normal hemoglobin, aged 16.0 to 18.5 years in whom simultaneous measurements of height, weight, arm circumference, and hematologic test results were also available. Crude analyses showed significantly lower systolic, diastolic, and mean arterial pressure in SS disease compared with control subjects with normal hemoglobin, but further analysis showed the systolic difference to be confined to males and all differences disappeared after adjustment for weight. No differences occurred in sickle cell-hemoglobin C disease.

CONCLUSIONS

These results suggest that the lower blood pressure in SS disease is attributable to low weight and that no further mechanisms need be postulated.

Authors+Show Affiliations

Medical Research Council Laboratories Jamaica, University of the West Indies, Kingston.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8494475

Citation

Homi, J, et al. "Adolescent Blood Pressure in a Cohort Study of Sickle Cell Disease." Archives of Internal Medicine, vol. 153, no. 10, 1993, pp. 1233-6.
Homi J, Homi-Levee L, Gentles S, et al. Adolescent blood pressure in a cohort study of sickle cell disease. Arch Intern Med. 1993;153(10):1233-6.
Homi, J., Homi-Levee, L., Gentles, S., Thomas, P., & Serjeant, G. (1993). Adolescent blood pressure in a cohort study of sickle cell disease. Archives of Internal Medicine, 153(10), 1233-6.
Homi J, et al. Adolescent Blood Pressure in a Cohort Study of Sickle Cell Disease. Arch Intern Med. 1993 May 24;153(10):1233-6. PubMed PMID: 8494475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adolescent blood pressure in a cohort study of sickle cell disease. AU - Homi,J, AU - Homi-Levee,L, AU - Gentles,S, AU - Thomas,P, AU - Serjeant,G, PY - 1993/5/24/pubmed PY - 1993/5/24/medline PY - 1993/5/24/entrez SP - 1233 EP - 6 JF - Archives of internal medicine JO - Arch Intern Med VL - 153 IS - 10 N2 - BACKGROUND: Previous studies on low blood pressure in patients with homozygous sickle cell (SS) disease have sought new hypotheses on the mechanism of low blood pressure but have not analyzed the role of known determinants such as weight. METHODS: Blood pressure has been measured by an automated oscillometric method in 220 patients with SS disease, 144 with sickle cell-hemoglobin C disease (both groups aged, 9.5 to 18.5 years) and 122 control subjects with a normal hemoglobin genotype (aged 16.0 to 18.5 years) participating in a cohort study from birth. RESULTS: Significant age-related increases in systolic and mean arterial pressure occurred in sickle cell-hemoglobin C disease but not in SS disease. Further analyses were confined to a subgroup of 51 patients with SS, 41 patients with sickle cell-hemoglobin C, and 97 subjects with normal hemoglobin, aged 16.0 to 18.5 years in whom simultaneous measurements of height, weight, arm circumference, and hematologic test results were also available. Crude analyses showed significantly lower systolic, diastolic, and mean arterial pressure in SS disease compared with control subjects with normal hemoglobin, but further analysis showed the systolic difference to be confined to males and all differences disappeared after adjustment for weight. No differences occurred in sickle cell-hemoglobin C disease. CONCLUSIONS: These results suggest that the lower blood pressure in SS disease is attributable to low weight and that no further mechanisms need be postulated. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/8494475/Adolescent_blood_pressure_in_a_cohort_study_of_sickle_cell_disease_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/153/pg/1233 DB - PRIME DP - Unbound Medicine ER -