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Treatment of diabetic ketoacidosis in dogs by continuous low-dose intravenous infusion of insulin.
J Am Vet Med Assoc. 1993 Apr 15; 202(8):1266-72.JA

Abstract

In a prospective clinical trial, low-dose, continuous, IV infusion of insulin (dosage, 2.2 U/kg of body weight, q 24 h) was used to treat 21 dogs with diabetic ketoacidosis. Mean (+/- SD) blood glucose concentration at the onset of treatment was 550 +/- 150 mg/dl and after 6 hours, was 350 +/- 106 mg/dl, with a mean decline of 34 +/- 16 mg/dl/h. By 12 hours, mean blood glucose was 246 +/- 85 mg/dl, with a mean decline of 28 +/- 14 mg/dl/h during the second 6 hours of treatment. Mean duration of treatment required to reach a blood glucose concentration < or = 250 mg/dl was 10 +/- 4 hours, with a range of 4 to 24 hours. Ketonuria was observed for 26 +/- 14 hours (range, 6 to 72 hours). Hypoglycemia developed in 3 of 21 dogs during treatment, but responded to IV administration of a glucose solution and to a reduction in rate of insulin delivery. Potassium supplementation was required in 15 of 21 dogs. Mean bicarbonate concentration was 11.6 +/- 3.4 mEq/L before treatment and was 18.2 +/- 0.7 mEq/L after 24 hours. Fifteen of 21 dogs (71%) survived to be discharged. Mean duration of treatment with the insulin infusion was 50 +/- 30 hours (range, 7 to 124 hours). In this series of dogs, continuous, low-dose, IV infusion of insulin provided a gradual and consistent reduction in blood glucose concentration while ketoacidosis, electrolyte balance, and dehydration were corrected.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Small Animal Surgery and Medicine, Auburn University, AL 36849.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

8496083

Citation

Macintire, D K.. "Treatment of Diabetic Ketoacidosis in Dogs By Continuous Low-dose Intravenous Infusion of Insulin." Journal of the American Veterinary Medical Association, vol. 202, no. 8, 1993, pp. 1266-72.
Macintire DK. Treatment of diabetic ketoacidosis in dogs by continuous low-dose intravenous infusion of insulin. J Am Vet Med Assoc. 1993;202(8):1266-72.
Macintire, D. K. (1993). Treatment of diabetic ketoacidosis in dogs by continuous low-dose intravenous infusion of insulin. Journal of the American Veterinary Medical Association, 202(8), 1266-72.
Macintire DK. Treatment of Diabetic Ketoacidosis in Dogs By Continuous Low-dose Intravenous Infusion of Insulin. J Am Vet Med Assoc. 1993 Apr 15;202(8):1266-72. PubMed PMID: 8496083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of diabetic ketoacidosis in dogs by continuous low-dose intravenous infusion of insulin. A1 - Macintire,D K, PY - 1993/4/15/pubmed PY - 1993/4/15/medline PY - 1993/4/15/entrez SP - 1266 EP - 72 JF - Journal of the American Veterinary Medical Association JO - J. Am. Vet. Med. Assoc. VL - 202 IS - 8 N2 - In a prospective clinical trial, low-dose, continuous, IV infusion of insulin (dosage, 2.2 U/kg of body weight, q 24 h) was used to treat 21 dogs with diabetic ketoacidosis. Mean (+/- SD) blood glucose concentration at the onset of treatment was 550 +/- 150 mg/dl and after 6 hours, was 350 +/- 106 mg/dl, with a mean decline of 34 +/- 16 mg/dl/h. By 12 hours, mean blood glucose was 246 +/- 85 mg/dl, with a mean decline of 28 +/- 14 mg/dl/h during the second 6 hours of treatment. Mean duration of treatment required to reach a blood glucose concentration < or = 250 mg/dl was 10 +/- 4 hours, with a range of 4 to 24 hours. Ketonuria was observed for 26 +/- 14 hours (range, 6 to 72 hours). Hypoglycemia developed in 3 of 21 dogs during treatment, but responded to IV administration of a glucose solution and to a reduction in rate of insulin delivery. Potassium supplementation was required in 15 of 21 dogs. Mean bicarbonate concentration was 11.6 +/- 3.4 mEq/L before treatment and was 18.2 +/- 0.7 mEq/L after 24 hours. Fifteen of 21 dogs (71%) survived to be discharged. Mean duration of treatment with the insulin infusion was 50 +/- 30 hours (range, 7 to 124 hours). In this series of dogs, continuous, low-dose, IV infusion of insulin provided a gradual and consistent reduction in blood glucose concentration while ketoacidosis, electrolyte balance, and dehydration were corrected.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/8496083/Treatment_of_diabetic_ketoacidosis_in_dogs_by_continuous_low_dose_intravenous_infusion_of_insulin_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -