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Evidence for increased androsterone metabolism in some normoandrogenic women with acne.
J Clin Endocrinol Metab. 1993 May; 76(5):1111-4.JC

Abstract

Increased androgen production from the ovary, adrenal or locally in skin has been implicated in the pathogenesis of acne. Recent data have provided evidence that androsterone (Ao) metabolism is exaggerated in acne and serum metabolites of Ao differentiate between acne and hirsutism in hyperandrogenic women. Here we have extended these studies to normoandrogenic women who have moderate to severe acne. We measured serum ovarian and adrenal androgens as well as the glucuronide and sulfate metabolites of Ao and 3 alpha-androstanediol which reflect, in part, peripheral androgen action. In a group of 15 well-selected normoandrogenic patients with acne, both serum Ao glucuronide (G) and Ao were elevated (P < 0.01; P < 0.05). The ratios of Ao G to androgen precursors of both ovarian and adrenal origin were elevated as was the ratio of Ao G/Ao (P < 0.05). These data suggest that increased Ao metabolism is a specific abnormality found in both normoandrogenic and hyperandrogenic women with acne. Our findings also provide a rationale for antiandrogen therapy at least in some normoandrogenic women with acne.

Authors+Show Affiliations

Cattedra di Endocrinologia, Universita di Palermo, Italy.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8496299

Citation

Carmina, E, and R A. Lobo. "Evidence for Increased Androsterone Metabolism in some Normoandrogenic Women With Acne." The Journal of Clinical Endocrinology and Metabolism, vol. 76, no. 5, 1993, pp. 1111-4.
Carmina E, Lobo RA. Evidence for increased androsterone metabolism in some normoandrogenic women with acne. J Clin Endocrinol Metab. 1993;76(5):1111-4.
Carmina, E., & Lobo, R. A. (1993). Evidence for increased androsterone metabolism in some normoandrogenic women with acne. The Journal of Clinical Endocrinology and Metabolism, 76(5), 1111-4.
Carmina E, Lobo RA. Evidence for Increased Androsterone Metabolism in some Normoandrogenic Women With Acne. J Clin Endocrinol Metab. 1993;76(5):1111-4. PubMed PMID: 8496299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for increased androsterone metabolism in some normoandrogenic women with acne. AU - Carmina,E, AU - Lobo,R A, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 1111 EP - 4 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 76 IS - 5 N2 - Increased androgen production from the ovary, adrenal or locally in skin has been implicated in the pathogenesis of acne. Recent data have provided evidence that androsterone (Ao) metabolism is exaggerated in acne and serum metabolites of Ao differentiate between acne and hirsutism in hyperandrogenic women. Here we have extended these studies to normoandrogenic women who have moderate to severe acne. We measured serum ovarian and adrenal androgens as well as the glucuronide and sulfate metabolites of Ao and 3 alpha-androstanediol which reflect, in part, peripheral androgen action. In a group of 15 well-selected normoandrogenic patients with acne, both serum Ao glucuronide (G) and Ao were elevated (P < 0.01; P < 0.05). The ratios of Ao G to androgen precursors of both ovarian and adrenal origin were elevated as was the ratio of Ao G/Ao (P < 0.05). These data suggest that increased Ao metabolism is a specific abnormality found in both normoandrogenic and hyperandrogenic women with acne. Our findings also provide a rationale for antiandrogen therapy at least in some normoandrogenic women with acne. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/8496299/Evidence_for_increased_androsterone_metabolism_in_some_normoandrogenic_women_with_acne_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.76.5.8496299 DB - PRIME DP - Unbound Medicine ER -