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A physician's prerogative to prescribe drugs for off-label uses during pregnancy.
Obstet Gynecol. 1993 Jun; 81(6):1052-5.OG

Abstract

Physicians frequently prescribe drugs for indications other than those on the product label. Reasons for such off-label use during pregnancy include: prevention of repetitive abortion, inhibition of premature labor, reduction of fetal or neonatal infection, reduction in development of preeclampsia and its complications, and ripening of the cervix or induction of labor. A physician has a legal right to prescribe for off-label indications despite regulatory, manufacturer, and cost constraints. Such prescribing habits would not be considered experimental if based on sound scientific evidence. Adequate and well-controlled studies are difficult to perform during pregnancy. Evidence of widespread use and support from another qualified clinician are methods of justifying off-label prescribing. Each patient is entitled to know why she and her fetus would benefit from the treatment and whether any unnecessary risk is anticipated. Legible documentation of these discussions in the medical records is important.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine, Oklahoma City.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8497349

Citation

Rayburn, W F.. "A Physician's Prerogative to Prescribe Drugs for Off-label Uses During Pregnancy." Obstetrics and Gynecology, vol. 81, no. 6, 1993, pp. 1052-5.
Rayburn WF. A physician's prerogative to prescribe drugs for off-label uses during pregnancy. Obstet Gynecol. 1993;81(6):1052-5.
Rayburn, W. F. (1993). A physician's prerogative to prescribe drugs for off-label uses during pregnancy. Obstetrics and Gynecology, 81(6), 1052-5.
Rayburn WF. A Physician's Prerogative to Prescribe Drugs for Off-label Uses During Pregnancy. Obstet Gynecol. 1993;81(6):1052-5. PubMed PMID: 8497349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A physician's prerogative to prescribe drugs for off-label uses during pregnancy. A1 - Rayburn,W F, PY - 1993/6/1/pubmed PY - 1993/6/1/medline PY - 1993/6/1/entrez SP - 1052 EP - 5 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 81 IS - 6 N2 - Physicians frequently prescribe drugs for indications other than those on the product label. Reasons for such off-label use during pregnancy include: prevention of repetitive abortion, inhibition of premature labor, reduction of fetal or neonatal infection, reduction in development of preeclampsia and its complications, and ripening of the cervix or induction of labor. A physician has a legal right to prescribe for off-label indications despite regulatory, manufacturer, and cost constraints. Such prescribing habits would not be considered experimental if based on sound scientific evidence. Adequate and well-controlled studies are difficult to perform during pregnancy. Evidence of widespread use and support from another qualified clinician are methods of justifying off-label prescribing. Each patient is entitled to know why she and her fetus would benefit from the treatment and whether any unnecessary risk is anticipated. Legible documentation of these discussions in the medical records is important. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/8497349/A_physician's_prerogative_to_prescribe_drugs_for_off_label_uses_during_pregnancy_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8497349.ui DB - PRIME DP - Unbound Medicine ER -