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Pharmacological analysis of the effects of metoclopramide on the guinea pig isolated stomach.
Gastroenterology. 1977 May; 72(5 Pt 1):864-9.G

Abstract

A pharmacological analysis has been made of the effects of metoclopramide on the contractile activity of isolated longitudinal muscle strips prepared from the guinea pig stomach. Metoclopramide produced up to 3-fold increases in the amplitude of the spontaneous contractions exhibited by such a preparation. This phenomenon was antagonized by hyoscine but not by tetrodotoxin nor by hexamethonium. The contractile response to transmural stimulation was also enhanced by metoclopramide, as was the response to extrinsic acetylcholine. Neural inhibitory systems were not affected by metoclopramide. The apparent sensitization to extrinsic acetylcholine was, however, prevented by tetrodotoxin and hexamethonium, implying that this effect depends upon ganglionic stimulation by acetylcholine. These results suggest that metoclopramide may act by increasing the amount of acetylcholine released at the postgangionic cholinergic nerve ending.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

849817

Citation

Hay, A M.. "Pharmacological Analysis of the Effects of Metoclopramide On the Guinea Pig Isolated Stomach." Gastroenterology, vol. 72, no. 5 Pt 1, 1977, pp. 864-9.
Hay AM. Pharmacological analysis of the effects of metoclopramide on the guinea pig isolated stomach. Gastroenterology. 1977;72(5 Pt 1):864-9.
Hay, A. M. (1977). Pharmacological analysis of the effects of metoclopramide on the guinea pig isolated stomach. Gastroenterology, 72(5 Pt 1), 864-9.
Hay AM. Pharmacological Analysis of the Effects of Metoclopramide On the Guinea Pig Isolated Stomach. Gastroenterology. 1977;72(5 Pt 1):864-9. PubMed PMID: 849817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological analysis of the effects of metoclopramide on the guinea pig isolated stomach. A1 - Hay,A M, PY - 1977/5/1/pubmed PY - 1977/5/1/medline PY - 1977/5/1/entrez SP - 864 EP - 9 JF - Gastroenterology JO - Gastroenterology VL - 72 IS - 5 Pt 1 N2 - A pharmacological analysis has been made of the effects of metoclopramide on the contractile activity of isolated longitudinal muscle strips prepared from the guinea pig stomach. Metoclopramide produced up to 3-fold increases in the amplitude of the spontaneous contractions exhibited by such a preparation. This phenomenon was antagonized by hyoscine but not by tetrodotoxin nor by hexamethonium. The contractile response to transmural stimulation was also enhanced by metoclopramide, as was the response to extrinsic acetylcholine. Neural inhibitory systems were not affected by metoclopramide. The apparent sensitization to extrinsic acetylcholine was, however, prevented by tetrodotoxin and hexamethonium, implying that this effect depends upon ganglionic stimulation by acetylcholine. These results suggest that metoclopramide may act by increasing the amount of acetylcholine released at the postgangionic cholinergic nerve ending. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/849817/Pharmacological_analysis_of_the_effects_of_metoclopramide_on_the_guinea_pig_isolated_stomach_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508577001449 DB - PRIME DP - Unbound Medicine ER -