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Risk factors for late-onset Alzheimer's disease: a population-based, case-control study.
Ann Neurol 1993; 33(3):258-66AN

Abstract

Our current knowledge of risk factors for Alzheimer's disease is limited and primarily addresses early-onset disease. This study aimed to determine the risk factors for late-onset Alzheimer's disease using a case-control approach. Ninety-eight cases and 216 controls were gathered from an ongoing population survey on aging and dementia in Stockholm (the Kungsholmen Project). We found a high relative risk (3.2; 95% confidence interval, 1.8-5.7) with the presence of at least one first-degree relative affected by dementia. Among all the other risk factors, alcohol abuse (relative risk, 4.4; 95% confidence interval, 1.4-13.8) and manual work (relative risk for men of 5.3; 95% confidence interval, 1.1-25.5) emerged as positively associated. No clear association was found with a family history of Parkinson disease, advanced parental age at index delivery, season of birth, or previous head trauma. In conclusion, our data suggest that the main risk factor for late-onset Alzheimer's disease is a family history of dementia, as has been previously reported for early-onset disease. Moreover, alcohol abuse and occupational exposure might play a specific role for this form of the disease.

Authors+Show Affiliations

Stockholm Gerontology Research Center, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8498809

Citation

Fratiglioni, L, et al. "Risk Factors for Late-onset Alzheimer's Disease: a Population-based, Case-control Study." Annals of Neurology, vol. 33, no. 3, 1993, pp. 258-66.
Fratiglioni L, Ahlbom A, Viitanen M, et al. Risk factors for late-onset Alzheimer's disease: a population-based, case-control study. Ann Neurol. 1993;33(3):258-66.
Fratiglioni, L., Ahlbom, A., Viitanen, M., & Winblad, B. (1993). Risk factors for late-onset Alzheimer's disease: a population-based, case-control study. Annals of Neurology, 33(3), pp. 258-66.
Fratiglioni L, et al. Risk Factors for Late-onset Alzheimer's Disease: a Population-based, Case-control Study. Ann Neurol. 1993;33(3):258-66. PubMed PMID: 8498809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for late-onset Alzheimer's disease: a population-based, case-control study. AU - Fratiglioni,L, AU - Ahlbom,A, AU - Viitanen,M, AU - Winblad,B, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 258 EP - 66 JF - Annals of neurology JO - Ann. Neurol. VL - 33 IS - 3 N2 - Our current knowledge of risk factors for Alzheimer's disease is limited and primarily addresses early-onset disease. This study aimed to determine the risk factors for late-onset Alzheimer's disease using a case-control approach. Ninety-eight cases and 216 controls were gathered from an ongoing population survey on aging and dementia in Stockholm (the Kungsholmen Project). We found a high relative risk (3.2; 95% confidence interval, 1.8-5.7) with the presence of at least one first-degree relative affected by dementia. Among all the other risk factors, alcohol abuse (relative risk, 4.4; 95% confidence interval, 1.4-13.8) and manual work (relative risk for men of 5.3; 95% confidence interval, 1.1-25.5) emerged as positively associated. No clear association was found with a family history of Parkinson disease, advanced parental age at index delivery, season of birth, or previous head trauma. In conclusion, our data suggest that the main risk factor for late-onset Alzheimer's disease is a family history of dementia, as has been previously reported for early-onset disease. Moreover, alcohol abuse and occupational exposure might play a specific role for this form of the disease. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/8498809/Risk_factors_for_late_onset_Alzheimer's_disease:_a_population_based_case_control_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1993&volume=33&issue=3&spage=258 DB - PRIME DP - Unbound Medicine ER -