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A population-based study of multiple sclerosis in twins: update.

Abstract

This study is a 7.5-year follow-up of a population-based series of twins with multiple sclerosis (MS) whose mean age now exceeds 50 years. The twin pairs were identified through the Canadian nationwide system of MS clinics and were drawn from a population of 5,463 patients. After 7.5 years, the monozygotic concordance rate increased from 25.9 to 30.8% and the dizygotic-like sex concordance rate from 2.4 to 4.7%. These results are very similar to those of other population-based studies and to our own modified replication twin data reported here. We interpret the data to mean that MS susceptibility is genetically influenced, and a single dominant or even a single recessive gene is unlikely to account for this effect. The difference in concordance rates suggests that at least two or more genes are operative. These data also have important implications for the nature of the environmental effect(s) in MS susceptibility. Most monozygotic twins are discordant even after a correction for age and magnetic resonance imaging findings. This unambiguously demonstrates the powerful effect of nonheritable factors.

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  • Authors+Show Affiliations

    ,

    University of British Columbia, Vancouver, Canada.

    , , , , , , , ,

    Source

    Annals of neurology 33:3 1993 Mar pg 281-5

    MeSH

    Adult
    Canada
    Diseases in Twins
    Female
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Multiple Sclerosis
    Population
    Twins, Dizygotic
    Twins, Monozygotic

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8498811

    Citation

    Sadovnick, A D., et al. "A Population-based Study of Multiple Sclerosis in Twins: Update." Annals of Neurology, vol. 33, no. 3, 1993, pp. 281-5.
    Sadovnick AD, Armstrong H, Rice GP, et al. A population-based study of multiple sclerosis in twins: update. Ann Neurol. 1993;33(3):281-5.
    Sadovnick, A. D., Armstrong, H., Rice, G. P., Bulman, D., Hashimoto, L., Paty, D. W., ... Murray, T. J. (1993). A population-based study of multiple sclerosis in twins: update. Annals of Neurology, 33(3), pp. 281-5.
    Sadovnick AD, et al. A Population-based Study of Multiple Sclerosis in Twins: Update. Ann Neurol. 1993;33(3):281-5. PubMed PMID: 8498811.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A population-based study of multiple sclerosis in twins: update. A1 - Sadovnick,A D, AU - Armstrong,H, AU - Rice,G P, AU - Bulman,D, AU - Hashimoto,L, AU - Paty,D W, AU - Hashimoto,S A, AU - Warren,S, AU - Hader,W, AU - Murray,T J, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 281 EP - 5 JF - Annals of neurology JO - Ann. Neurol. VL - 33 IS - 3 N2 - This study is a 7.5-year follow-up of a population-based series of twins with multiple sclerosis (MS) whose mean age now exceeds 50 years. The twin pairs were identified through the Canadian nationwide system of MS clinics and were drawn from a population of 5,463 patients. After 7.5 years, the monozygotic concordance rate increased from 25.9 to 30.8% and the dizygotic-like sex concordance rate from 2.4 to 4.7%. These results are very similar to those of other population-based studies and to our own modified replication twin data reported here. We interpret the data to mean that MS susceptibility is genetically influenced, and a single dominant or even a single recessive gene is unlikely to account for this effect. The difference in concordance rates suggests that at least two or more genes are operative. These data also have important implications for the nature of the environmental effect(s) in MS susceptibility. Most monozygotic twins are discordant even after a correction for age and magnetic resonance imaging findings. This unambiguously demonstrates the powerful effect of nonheritable factors. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/8498811/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1993&volume=33&issue=3&spage=281 DB - PRIME DP - Unbound Medicine ER -