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A population-based study of multiple sclerosis in twins: update.
Ann Neurol 1993; 33(3):281-5AN

Abstract

This study is a 7.5-year follow-up of a population-based series of twins with multiple sclerosis (MS) whose mean age now exceeds 50 years. The twin pairs were identified through the Canadian nationwide system of MS clinics and were drawn from a population of 5,463 patients. After 7.5 years, the monozygotic concordance rate increased from 25.9 to 30.8% and the dizygotic-like sex concordance rate from 2.4 to 4.7%. These results are very similar to those of other population-based studies and to our own modified replication twin data reported here. We interpret the data to mean that MS susceptibility is genetically influenced, and a single dominant or even a single recessive gene is unlikely to account for this effect. The difference in concordance rates suggests that at least two or more genes are operative. These data also have important implications for the nature of the environmental effect(s) in MS susceptibility. Most monozygotic twins are discordant even after a correction for age and magnetic resonance imaging findings. This unambiguously demonstrates the powerful effect of nonheritable factors.

Authors+Show Affiliations

University of British Columbia, Vancouver, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8498811

Citation

Sadovnick, A D., et al. "A Population-based Study of Multiple Sclerosis in Twins: Update." Annals of Neurology, vol. 33, no. 3, 1993, pp. 281-5.
Sadovnick AD, Armstrong H, Rice GP, et al. A population-based study of multiple sclerosis in twins: update. Ann Neurol. 1993;33(3):281-5.
Sadovnick, A. D., Armstrong, H., Rice, G. P., Bulman, D., Hashimoto, L., Paty, D. W., ... Murray, T. J. (1993). A population-based study of multiple sclerosis in twins: update. Annals of Neurology, 33(3), pp. 281-5.
Sadovnick AD, et al. A Population-based Study of Multiple Sclerosis in Twins: Update. Ann Neurol. 1993;33(3):281-5. PubMed PMID: 8498811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A population-based study of multiple sclerosis in twins: update. A1 - Sadovnick,A D, AU - Armstrong,H, AU - Rice,G P, AU - Bulman,D, AU - Hashimoto,L, AU - Paty,D W, AU - Hashimoto,S A, AU - Warren,S, AU - Hader,W, AU - Murray,T J, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 281 EP - 5 JF - Annals of neurology JO - Ann. Neurol. VL - 33 IS - 3 N2 - This study is a 7.5-year follow-up of a population-based series of twins with multiple sclerosis (MS) whose mean age now exceeds 50 years. The twin pairs were identified through the Canadian nationwide system of MS clinics and were drawn from a population of 5,463 patients. After 7.5 years, the monozygotic concordance rate increased from 25.9 to 30.8% and the dizygotic-like sex concordance rate from 2.4 to 4.7%. These results are very similar to those of other population-based studies and to our own modified replication twin data reported here. We interpret the data to mean that MS susceptibility is genetically influenced, and a single dominant or even a single recessive gene is unlikely to account for this effect. The difference in concordance rates suggests that at least two or more genes are operative. These data also have important implications for the nature of the environmental effect(s) in MS susceptibility. Most monozygotic twins are discordant even after a correction for age and magnetic resonance imaging findings. This unambiguously demonstrates the powerful effect of nonheritable factors. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/8498811/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1993&volume=33&issue=3&spage=281 DB - PRIME DP - Unbound Medicine ER -